Brain flow changes before and after deep brain stimulation of the subthalamic nucleus in Parkinson's disease

A. Antonini, G. Marotta, R. Benti, A. Landi, R. De Notaris, C. Mariani, P. Gerundini, G. Pezzoli, S. M. Gaini

Research output: Contribution to journalArticlepeer-review

Abstract

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) markedly improves motor symptoms and reduces medication needs in Parkinson's disease (PD) patients. However, its effect on brain function has remained unclear. We used SPECT and the tracer ECD to measure regional cerebral blood flow before and 6 months after DBS of the STN in 22 PD patients and 13 healthy controls. PD patients were divided into good and poor responders to DBS, if changes in "off" UPDRS motor scores after surgery were >60% or

Original languageEnglish
Pages (from-to)151-152
Number of pages2
JournalNeurological Sciences
Volume24
Issue number3
DOIs
Publication statusPublished - Oct 2003

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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