Abstract
BACKGROUND AND PURPOSE - In migraine patients, functional imaging studies have shown changes in several brain gray matter (GM) regions. However, 1.5-T MRI has failed to detect any structural abnormality of these regions. We used a 3-T MRI scanner and voxel-based morphometry (VBM) to assess whether GM density abnormalities can be seen in patients with migraine with T2-visible abnormalities and to grade their extent. METHODS - In 16 migraine patients with T2-visible abnormalities and 15 matched controls, we acquired a T2-weighted and a high-resolution T1-weighted sequence. Lesion loads were measured on T2-weighted images. An optimized version of VBM analysis was used to assess regional differences in GM densities on T1-weighted scans of patients versus controls. Statistical parametric maps were thresholded at P
| Original language | English |
|---|---|
| Pages (from-to) | 1765-1770 |
| Number of pages | 6 |
| Journal | Stroke |
| Volume | 37 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 2006 |
Fingerprint
Keywords
- Magnetic resonance imaging
- Migraine
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Neuroscience(all)
Cite this
Brain gray matter changes in migraine patients with T2-visible lesions : A 3-T MRI study. / Rocca, Maria A.; Ceccarelli, Antonia; Falini, Andrea; Colombo, Bruno; Tortorella, Paola; Bernasconi, Luca; Comi, Giancarlo; Scotti, Giuseppe; Filippi, Massimo.
In: Stroke, Vol. 37, No. 7, 07.2006, p. 1765-1770.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Brain gray matter changes in migraine patients with T2-visible lesions
T2 - A 3-T MRI study
AU - Rocca, Maria A.
AU - Ceccarelli, Antonia
AU - Falini, Andrea
AU - Colombo, Bruno
AU - Tortorella, Paola
AU - Bernasconi, Luca
AU - Comi, Giancarlo
AU - Scotti, Giuseppe
AU - Filippi, Massimo
PY - 2006/7
Y1 - 2006/7
N2 - BACKGROUND AND PURPOSE - In migraine patients, functional imaging studies have shown changes in several brain gray matter (GM) regions. However, 1.5-T MRI has failed to detect any structural abnormality of these regions. We used a 3-T MRI scanner and voxel-based morphometry (VBM) to assess whether GM density abnormalities can be seen in patients with migraine with T2-visible abnormalities and to grade their extent. METHODS - In 16 migraine patients with T2-visible abnormalities and 15 matched controls, we acquired a T2-weighted and a high-resolution T1-weighted sequence. Lesion loads were measured on T2-weighted images. An optimized version of VBM analysis was used to assess regional differences in GM densities on T1-weighted scans of patients versus controls. Statistical parametric maps were thresholded at P
AB - BACKGROUND AND PURPOSE - In migraine patients, functional imaging studies have shown changes in several brain gray matter (GM) regions. However, 1.5-T MRI has failed to detect any structural abnormality of these regions. We used a 3-T MRI scanner and voxel-based morphometry (VBM) to assess whether GM density abnormalities can be seen in patients with migraine with T2-visible abnormalities and to grade their extent. METHODS - In 16 migraine patients with T2-visible abnormalities and 15 matched controls, we acquired a T2-weighted and a high-resolution T1-weighted sequence. Lesion loads were measured on T2-weighted images. An optimized version of VBM analysis was used to assess regional differences in GM densities on T1-weighted scans of patients versus controls. Statistical parametric maps were thresholded at P
KW - Magnetic resonance imaging
KW - Migraine
UR - http://www.scopus.com/inward/record.url?scp=33745946146&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33745946146&partnerID=8YFLogxK
U2 - 10.1161/01.STR.0000226589.00599.4d
DO - 10.1161/01.STR.0000226589.00599.4d
M3 - Article
C2 - 16728687
AN - SCOPUS:33745946146
VL - 37
SP - 1765
EP - 1770
JO - Stroke
JF - Stroke
SN - 0039-2499
IS - 7
ER -