Brain gray matter changes in migraine patients with T2-visible lesions: A 3-T MRI study

Maria A. Rocca, Antonia Ceccarelli, Andrea Falini, Bruno Colombo, Paola Tortorella, Luca Bernasconi, Giancarlo Comi, Giuseppe Scotti, Massimo Filippi

Research output: Contribution to journalArticlepeer-review


BACKGROUND AND PURPOSE - In migraine patients, functional imaging studies have shown changes in several brain gray matter (GM) regions. However, 1.5-T MRI has failed to detect any structural abnormality of these regions. We used a 3-T MRI scanner and voxel-based morphometry (VBM) to assess whether GM density abnormalities can be seen in patients with migraine with T2-visible abnormalities and to grade their extent. METHODS - In 16 migraine patients with T2-visible abnormalities and 15 matched controls, we acquired a T2-weighted and a high-resolution T1-weighted sequence. Lesion loads were measured on T2-weighted images. An optimized version of VBM analysis was used to assess regional differences in GM densities on T1-weighted scans of patients versus controls. Statistical parametric maps were thresholded at P

Original languageEnglish
Pages (from-to)1765-1770
Number of pages6
Issue number7
Publication statusPublished - Jul 2006


  • Magnetic resonance imaging
  • Migraine

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)


Dive into the research topics of 'Brain gray matter changes in migraine patients with T2-visible lesions: A 3-T MRI study'. Together they form a unique fingerprint.

Cite this