Brain gray matter changes in migraine patients with T2-visible lesions: A 3-T MRI study

Maria A. Rocca, Antonia Ceccarelli, Andrea Falini, Bruno Colombo, Paola Tortorella, Luca Bernasconi, Giancarlo Comi, Giuseppe Scotti, Massimo Filippi

Research output: Contribution to journalArticle

Abstract

BACKGROUND AND PURPOSE - In migraine patients, functional imaging studies have shown changes in several brain gray matter (GM) regions. However, 1.5-T MRI has failed to detect any structural abnormality of these regions. We used a 3-T MRI scanner and voxel-based morphometry (VBM) to assess whether GM density abnormalities can be seen in patients with migraine with T2-visible abnormalities and to grade their extent. METHODS - In 16 migraine patients with T2-visible abnormalities and 15 matched controls, we acquired a T2-weighted and a high-resolution T1-weighted sequence. Lesion loads were measured on T2-weighted images. An optimized version of VBM analysis was used to assess regional differences in GM densities on T1-weighted scans of patients versus controls. Statistical parametric maps were thresholded at P

Original languageEnglish
Pages (from-to)1765-1770
Number of pages6
JournalStroke
Volume37
Issue number7
DOIs
Publication statusPublished - Jul 2006

Fingerprint

Migraine Disorders
Brain
Gray Matter

Keywords

  • Magnetic resonance imaging
  • Migraine

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

Brain gray matter changes in migraine patients with T2-visible lesions : A 3-T MRI study. / Rocca, Maria A.; Ceccarelli, Antonia; Falini, Andrea; Colombo, Bruno; Tortorella, Paola; Bernasconi, Luca; Comi, Giancarlo; Scotti, Giuseppe; Filippi, Massimo.

In: Stroke, Vol. 37, No. 7, 07.2006, p. 1765-1770.

Research output: Contribution to journalArticle

Rocca, Maria A. ; Ceccarelli, Antonia ; Falini, Andrea ; Colombo, Bruno ; Tortorella, Paola ; Bernasconi, Luca ; Comi, Giancarlo ; Scotti, Giuseppe ; Filippi, Massimo. / Brain gray matter changes in migraine patients with T2-visible lesions : A 3-T MRI study. In: Stroke. 2006 ; Vol. 37, No. 7. pp. 1765-1770.
@article{2c9cadfafdb140da8862c353b377cc13,
title = "Brain gray matter changes in migraine patients with T2-visible lesions: A 3-T MRI study",
abstract = "BACKGROUND AND PURPOSE - In migraine patients, functional imaging studies have shown changes in several brain gray matter (GM) regions. However, 1.5-T MRI has failed to detect any structural abnormality of these regions. We used a 3-T MRI scanner and voxel-based morphometry (VBM) to assess whether GM density abnormalities can be seen in patients with migraine with T2-visible abnormalities and to grade their extent. METHODS - In 16 migraine patients with T2-visible abnormalities and 15 matched controls, we acquired a T2-weighted and a high-resolution T1-weighted sequence. Lesion loads were measured on T2-weighted images. An optimized version of VBM analysis was used to assess regional differences in GM densities on T1-weighted scans of patients versus controls. Statistical parametric maps were thresholded at P",
keywords = "Magnetic resonance imaging, Migraine",
author = "Rocca, {Maria A.} and Antonia Ceccarelli and Andrea Falini and Bruno Colombo and Paola Tortorella and Luca Bernasconi and Giancarlo Comi and Giuseppe Scotti and Massimo Filippi",
year = "2006",
month = "7",
doi = "10.1161/01.STR.0000226589.00599.4d",
language = "English",
volume = "37",
pages = "1765--1770",
journal = "Stroke",
issn = "0039-2499",
publisher = "Lippincott Williams and Wilkins",
number = "7",

}

TY - JOUR

T1 - Brain gray matter changes in migraine patients with T2-visible lesions

T2 - A 3-T MRI study

AU - Rocca, Maria A.

AU - Ceccarelli, Antonia

AU - Falini, Andrea

AU - Colombo, Bruno

AU - Tortorella, Paola

AU - Bernasconi, Luca

AU - Comi, Giancarlo

AU - Scotti, Giuseppe

AU - Filippi, Massimo

PY - 2006/7

Y1 - 2006/7

N2 - BACKGROUND AND PURPOSE - In migraine patients, functional imaging studies have shown changes in several brain gray matter (GM) regions. However, 1.5-T MRI has failed to detect any structural abnormality of these regions. We used a 3-T MRI scanner and voxel-based morphometry (VBM) to assess whether GM density abnormalities can be seen in patients with migraine with T2-visible abnormalities and to grade their extent. METHODS - In 16 migraine patients with T2-visible abnormalities and 15 matched controls, we acquired a T2-weighted and a high-resolution T1-weighted sequence. Lesion loads were measured on T2-weighted images. An optimized version of VBM analysis was used to assess regional differences in GM densities on T1-weighted scans of patients versus controls. Statistical parametric maps were thresholded at P

AB - BACKGROUND AND PURPOSE - In migraine patients, functional imaging studies have shown changes in several brain gray matter (GM) regions. However, 1.5-T MRI has failed to detect any structural abnormality of these regions. We used a 3-T MRI scanner and voxel-based morphometry (VBM) to assess whether GM density abnormalities can be seen in patients with migraine with T2-visible abnormalities and to grade their extent. METHODS - In 16 migraine patients with T2-visible abnormalities and 15 matched controls, we acquired a T2-weighted and a high-resolution T1-weighted sequence. Lesion loads were measured on T2-weighted images. An optimized version of VBM analysis was used to assess regional differences in GM densities on T1-weighted scans of patients versus controls. Statistical parametric maps were thresholded at P

KW - Magnetic resonance imaging

KW - Migraine

UR - http://www.scopus.com/inward/record.url?scp=33745946146&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745946146&partnerID=8YFLogxK

U2 - 10.1161/01.STR.0000226589.00599.4d

DO - 10.1161/01.STR.0000226589.00599.4d

M3 - Article

C2 - 16728687

AN - SCOPUS:33745946146

VL - 37

SP - 1765

EP - 1770

JO - Stroke

JF - Stroke

SN - 0039-2499

IS - 7

ER -