TY - JOUR
T1 - Brain imaging in glaucoma from clinical studies to clinical practice
AU - Garaci, Francesco
AU - Altobelli, Simone
AU - Toschi, Nicola
AU - Mancino, Raffaele
AU - Nucci, Carlo
AU - Schillaci, Orazio
AU - Floris, Roberto
PY - 2015
Y1 - 2015
N2 - Recent advances in Magnetic Resonance Imaging (MRI) technology have brought new insight in central nervous system (CNS) manifestation of glaucoma. New MR techniques allowed to identify in vivo and noninvasively alterations along all the visual pathway in both early and late stages of the disease. Conventional neuroimaging still plays an important role, mostly in the anatomy description and in the differential diagnosis with space occupying lesions but it should be supported by other advanced MR techniques such as diffusion tensor imaging, functional imaging (BOLD-ASL), and magnetic resonance spectroscopy, which offer the possibility to investigate deep white matter tracts integrity and cortical gray matter changes. In a future perspective, MR quantification of CNS damage associated with glaucoma will be of pivotal importance for prognostic stratification and evaluation of neuroprotective therapy response.
AB - Recent advances in Magnetic Resonance Imaging (MRI) technology have brought new insight in central nervous system (CNS) manifestation of glaucoma. New MR techniques allowed to identify in vivo and noninvasively alterations along all the visual pathway in both early and late stages of the disease. Conventional neuroimaging still plays an important role, mostly in the anatomy description and in the differential diagnosis with space occupying lesions but it should be supported by other advanced MR techniques such as diffusion tensor imaging, functional imaging (BOLD-ASL), and magnetic resonance spectroscopy, which offer the possibility to investigate deep white matter tracts integrity and cortical gray matter changes. In a future perspective, MR quantification of CNS damage associated with glaucoma will be of pivotal importance for prognostic stratification and evaluation of neuroprotective therapy response.
KW - Diffusion tensor imaging
KW - FMRI
KW - Glaucoma
KW - MR imaging
KW - MR spectroscopy
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U2 - 10.1016/bs.pbr.2015.06.004
DO - 10.1016/bs.pbr.2015.06.004
M3 - Article
AN - SCOPUS:84940973881
JO - Progress in Brain Research
JF - Progress in Brain Research
SN - 0079-6123
ER -