Brain imaging in glaucoma from clinical studies to clinical practice

Francesco Garaci, Simone Altobelli, Nicola Toschi, Raffaele Mancino, Carlo Nucci, Orazio Schillaci, Roberto Floris

Research output: Contribution to journalArticle

Abstract

Recent advances in Magnetic Resonance Imaging (MRI) technology have brought new insight in central nervous system (CNS) manifestation of glaucoma. New MR techniques allowed to identify in vivo and noninvasively alterations along all the visual pathway in both early and late stages of the disease. Conventional neuroimaging still plays an important role, mostly in the anatomy description and in the differential diagnosis with space occupying lesions but it should be supported by other advanced MR techniques such as diffusion tensor imaging, functional imaging (BOLD-ASL), and magnetic resonance spectroscopy, which offer the possibility to investigate deep white matter tracts integrity and cortical gray matter changes. In a future perspective, MR quantification of CNS damage associated with glaucoma will be of pivotal importance for prognostic stratification and evaluation of neuroprotective therapy response.

Original languageEnglish
JournalProgress in Brain Research
DOIs
Publication statusAccepted/In press - 2015

Keywords

  • Diffusion tensor imaging
  • FMRI
  • Glaucoma
  • MR imaging
  • MR spectroscopy

ASJC Scopus subject areas

  • Neuroscience(all)

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    Garaci, F., Altobelli, S., Toschi, N., Mancino, R., Nucci, C., Schillaci, O., & Floris, R. (Accepted/In press). Brain imaging in glaucoma from clinical studies to clinical practice. Progress in Brain Research. https://doi.org/10.1016/bs.pbr.2015.06.004