Brain kinins are responsible for the pressor effect of intracerebroventricular captopril in spontaneously hypertensive rats

Paolo Madeddu, Nicola Glorioso, Aldo Soro, Giancarlo Tonolo, Paolo Manunta, Chiara Troffa, Maria Piera Demontis, Maria Vittoria Varoni, Vittorio Anania

Research output: Contribution to journalArticle

Abstract

The role of the brain kallikrein-kinin system in the regulation of arterial blood pressure of normotensive and spontaneously hypertensive rats was evaluated. Intracerebroventricular administration of the kinin antagonist [DArg0]Hyp3-Thi5,8[DPhe7]bradykinin caused no change in mean blood pressure in Wistar-Kyoto, Sprague-Dawley, or spontaneously hypertensive rats. The antagonist proved to be very potent in blocking the pressor effect of intracerebroventricular bradykinin (32±3 vs. 3±1 mm Hg,p2, 48±3 vs. 47±8 mm Hg; norepinephrine, 17±2 vs. 18±2 mm Hg; leucine-enkephaline, 15±2 vs. 16±1 mm Hg; neurotensin, 18±2 vs. 19±1 mm Hg; substance P, 19±2 vs. 19±2 mm Hg). Intracerebroventricular administration of 1 mg captopril, an inhibitor of kininase II (one of the enzymes responsible for kinin degradation), caused no change in mean blood pressure in normotensive rats, whereas it increased mean blood pressure by 44±9 mm Hg (p

Original languageEnglish
Pages (from-to)407-412
Number of pages6
JournalHypertension
Volume15
Issue number4
Publication statusPublished - Apr 1990

Keywords

  • Captopril
  • Central nervous system
  • Kallikrein-kinin system
  • Kinin antagonist
  • Renin-angiotensin system

ASJC Scopus subject areas

  • Internal Medicine

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    Madeddu, P., Glorioso, N., Soro, A., Tonolo, G., Manunta, P., Troffa, C., Demontis, M. P., Varoni, M. V., & Anania, V. (1990). Brain kinins are responsible for the pressor effect of intracerebroventricular captopril in spontaneously hypertensive rats. Hypertension, 15(4), 407-412.