Brain lesion scores obtained using a simple semi-quantitative scale from MR imaging are associated with motor function, communication and cognition in dyskinetic cerebral palsy

Olga Laporta-Hoyos, Simona Fiori, Kerstin Pannek, Júlia Ballester-Plané, David Leiva, Lee B. Reid, Alex M. Pagnozzi, Élida Vázquez, Ignacio Delgado, Alfons Macaya, Roser Pueyo, Roslyn N. Boyd

Research output: Contribution to journalArticle

Abstract

Purpose: To characterise brain lesions in dyskinetic cerebral palsy (DCP) using the semi-quantitative scale for structural MRI (sqMRI) and to investigate their relationship with motor, communication and cognitive function. Materials and methods: Thirty-nine participants (19 females, median age 21y) with DCP were assessed in terms of motor function, communication and a variety of cognitive domains. Whole-head magnetic resonance imaging (MRI) was performed including T1-MPRAGE, T2 turbo spin echo (axial plane), and fluid attenuated inversion recovery images (FLAIR). A child neurologist visually assessed images for brain lesions and scored these using the sqMRI. Ordinal, Poisson and binomial negative regression models identified which brain lesions accounted for clinical outcomes. Results: Brain lesions were most frequently located in the ventral posterior lateral thalamus and the frontal lobe. Gross (B = 0.180, p <.001; B = 0.658, p <.001) and fine (B = 0.136, p =.003; B = 0.540, p <.001) motor function were associated with global sqMRI score and parietal involvement. Communication functioning was associated with putamen involvement (B = 0.747, p <.028). Intellectual functioning was associated with global sqMRI score and posterior thalamus involvement (B = −0.018, p <.001; B = −0.192, p <.001). Selective attention was associated with global sqMRI score (B = −0.035, p <.001), parietal (B = −0.063, p =.023), and corpus callosum involvement (B = −0.448, p <.001). Visuospatial and visuoperceptive abilities were associated with global sqMRI score (B = −0.078, p =.007) and medial dorsal thalamus involvement (B = −0.139, p <.012), respectively. Conclusions: Key clinical outcomes in DCP are associated with specific observable brain lesions as indexed by a simple lesion scoring system that relies only on standard clinical MRI.

Original languageEnglish
Pages (from-to)892-900
Number of pages9
JournalNeuroImage: Clinical
Volume19
DOIs
Publication statusPublished - Jan 1 2018

Keywords

  • Communication
  • Dyskinetic cerebral palsy
  • Frontal lobe
  • Intellectual functioning
  • Ventral posterior lateral thalamus
  • Visuoperception

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology
  • Cognitive Neuroscience

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    Laporta-Hoyos, O., Fiori, S., Pannek, K., Ballester-Plané, J., Leiva, D., Reid, L. B., Pagnozzi, A. M., Vázquez, É., Delgado, I., Macaya, A., Pueyo, R., & Boyd, R. N. (2018). Brain lesion scores obtained using a simple semi-quantitative scale from MR imaging are associated with motor function, communication and cognition in dyskinetic cerebral palsy. NeuroImage: Clinical, 19, 892-900. https://doi.org/10.1016/j.nicl.2018.06.015