Brain levels of imipramine and desipramine after combined treatment with these drugs in rats

A. Jori, D. Bernardi, G. Muscettola, S. Garattini

Research output: Contribution to journalArticle

Abstract

Rats were treated with a combination of imipramine (IMI) and desipramine (DMI). Tissue concentrations of the drugs were determined at various times and compared with the levels obtained after treatment with either IMI or DMI alone. Brain concentrations of IMI increased when rats were pretreated with DMI. The concentrations of brain and plasma DMI were higher than the sum of the concentrations attained after addition of DMI and IMI separately. However, the rates of removal of IMI from the brain were similar after single or combined treatment. The results are examined in view of the favorable effects obtained in clinical trials with combinations of these antidepressent drugs.

Original languageEnglish
Pages (from-to)85-90
Number of pages6
JournalEuropean Journal of Pharmacology
Volume15
Issue number1
DOIs
Publication statusPublished - 1971

Keywords

  • Desipramine
  • Imipramine
  • Tricyclic antidepressant drugs

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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