TY - JOUR
T1 - Brain levels of imipramine and desipramine after combined treatment with these drugs in rats
AU - Jori, A.
AU - Bernardi, D.
AU - Muscettola, G.
AU - Garattini, S.
PY - 1971
Y1 - 1971
N2 - Rats were treated with a combination of imipramine (IMI) and desipramine (DMI). Tissue concentrations of the drugs were determined at various times and compared with the levels obtained after treatment with either IMI or DMI alone. Brain concentrations of IMI increased when rats were pretreated with DMI. The concentrations of brain and plasma DMI were higher than the sum of the concentrations attained after addition of DMI and IMI separately. However, the rates of removal of IMI from the brain were similar after single or combined treatment. The results are examined in view of the favorable effects obtained in clinical trials with combinations of these antidepressent drugs.
AB - Rats were treated with a combination of imipramine (IMI) and desipramine (DMI). Tissue concentrations of the drugs were determined at various times and compared with the levels obtained after treatment with either IMI or DMI alone. Brain concentrations of IMI increased when rats were pretreated with DMI. The concentrations of brain and plasma DMI were higher than the sum of the concentrations attained after addition of DMI and IMI separately. However, the rates of removal of IMI from the brain were similar after single or combined treatment. The results are examined in view of the favorable effects obtained in clinical trials with combinations of these antidepressent drugs.
KW - Desipramine
KW - Imipramine
KW - Tricyclic antidepressant drugs
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U2 - 10.1016/0014-2999(71)90082-3
DO - 10.1016/0014-2999(71)90082-3
M3 - Article
C2 - 5161343
AN - SCOPUS:0015069827
VL - 15
SP - 85
EP - 90
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 1
ER -