Rats were treated with a combination of imipramine (IMI) and desipramine (DMI). Tissue concentrations of the drugs were determined at various times and compared with the levels obtained after treatment with either IMI or DMI alone. Brain concentrations of IMI increased when rats were pretreated with DMI. The concentrations of brain and plasma DMI were higher than the sum of the concentrations attained after addition of DMI and IMI separately. However, the rates of removal of IMI from the brain were similar after single or combined treatment. The results are examined in view of the favorable effects obtained in clinical trials with combinations of these antidepressent drugs.
- Tricyclic antidepressant drugs
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience