Brain levels of metrazol determined with a new gas chromatographic procedure

F. Marcucci, M. L. Airoldi, E. Mussini, S. Garattini

Research output: Contribution to journalArticle

Abstract

A gas chromatographic method for the determination of metrazol in the brain after the administration of this convulsant drug in rats and mice is presented. The peak levels of brain metrazol were reached at the same time in both species, but they were lower and declined faster in mice than in rats, after comparable doses of injected metrazol. The threshold for convulsions was different in the two animal species; in rats it was approximately 45 μg of metrazol per g of brain and in mice approximately 37 μg/g.

Original languageEnglish
Pages (from-to)219-221
Number of pages3
JournalEuropean Journal of Pharmacology
Volume16
Issue number2
DOIs
Publication statusPublished - 1971

Keywords

  • Brain
  • Metrazol
  • Mouse
  • Rat

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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