A gas chromatographic method for the determination of metrazol in the brain after the administration of this convulsant drug in rats and mice is presented. The peak levels of brain metrazol were reached at the same time in both species, but they were lower and declined faster in mice than in rats, after comparable doses of injected metrazol. The threshold for convulsions was different in the two animal species; in rats it was approximately 45 μg of metrazol per g of brain and in mice approximately 37 μg/g.
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience