Brain magnetic resonance imaging in congenital hypothyroid infants at diagnosis

V. Siragusa, S. Boffelli, G. Weber, F. Triulzi, S. Orezzi, G. Scotti, G. Chiumello

Research output: Contribution to journalArticle

Abstract

The aim of our study was to investigate the central nervous system (CNS) morphology and myelination with magnetic resonance imaging (MRI) in congenital hypothyroid (CH) infants detected by neonatal screening before replacement therapy. We studied 11 CH infants, 9 girls and 2 boys, mean age 22 days, 3 with aplasia, 5 with ectopia, 2 with hypoplasia of the thyroid gland, 1 with unknown diagnosis. As normal controls 22 term newborns (38 to 41 weeks of gestational age) were studied. MRI studies were performed with a 1.5-T magnet, extremity coil, T1-weighted and heavily T2-sequences axial sections were obtained. No sedation was needed for the MRI studies. MRI brain examination was normal in all patients compared with controls. In particular, no differences in the myelination patterns of the brain were observed between normal subjects and patients with hypothyroidism. Our study shows no morphological brain abnormalities in CH infants detected by neonatal screening before replacement therapy. Perinatal hypothyroidism seems to have no effect on CNS structures.

Original languageEnglish
Pages (from-to)761-764
Number of pages4
JournalThyroid
Volume7
Issue number5
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Endocrinology

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    Siragusa, V., Boffelli, S., Weber, G., Triulzi, F., Orezzi, S., Scotti, G., & Chiumello, G. (1997). Brain magnetic resonance imaging in congenital hypothyroid infants at diagnosis. Thyroid, 7(5), 761-764.