Brain metabolic alterations herald falls in patients with Parkinson’s disease

Ioannis U. Isaias; Joachim Brumberg; Nicoló G. Pozzi; Chiara Palmisano; Andrea Canessa; Giorgio Marotta; Jens Volkmann; Gianni Pezzoli

doi:10.1002/acn3.51013

Brain metabolic alterations herald falls in patients with Parkinson’s disease

Ioannis U. Isaias, Joachim Brumberg, Nicoló G. Pozzi, Chiara Palmisano, Andrea Canessa, Giorgio Marotta, Jens Volkmann, Gianni Pezzoli

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

Pathophysiological understanding of gait and balance disorders in Parkinson’s disease is insufficient and late recognition of fall risk limits efficacious follow-up to prevent or delay falls. We show a distinctive reduction of glucose metabolism in the left posterior parietal cortex, with increased metabolic activity in the cerebellum, in parkinsonian patients 6–8 months before their first fall episode. Falls in Parkinson’s disease may arise from altered cortical processing of body spatial orientation, possibly predicted by abnormal cortical metabolism.

Original language	English
Pages (from-to)	579-583
Journal	Annals of Clinical and Translational Neurology
Volume	7
Issue number	4
DOIs	https://doi.org/10.1002/acn3.51013
Publication status	Published - 2020

ASJC Scopus subject areas

Neuroscience(all)
Clinical Neurology

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Brain metabolic alterations herald falls in patients with Parkinson’s disease. / Isaias, Ioannis U.; Brumberg, Joachim; Pozzi, Nicoló G.; Palmisano, Chiara; Canessa, Andrea; Marotta, Giorgio; Volkmann, Jens; Pezzoli, Gianni.

In: Annals of Clinical and Translational Neurology, Vol. 7, No. 4, 2020, p. 579-583.

Research output: Contribution to journal › Article › peer-review

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