Brain metastases from hepatocellular carcinoma: A case report

M. Salvati, M. Cimatti, A. Frati, A. Santoro, F. M. Gagliardi, B. Cucciniello

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Brain metastasis from hepatocarcinoma are a decidedly rare occurrence in countries where this pathology is most frequent. The authors describe a case of metastases from hepatocellular carcinoma in a patient suffering from post-HBV hepatic cirrhosis with hemorrhagic onset. The "stroke-like" presentation of the cerebral localization of the disease can be explained by both the important vascularization of the tumor and the frequent hemocoagulative alterations caused by the cirrhosis. The importance of diagnostic neuroradiology is briefly addressed, with reference to the fundamental role played by MRI. Surgery of these lesions does not present any particular technical problems as long as they are located in accessible areas and the patient's general and neurological conditions allow it. Postoperative radiotherapy seems to improve the quality and quantity of residual life, although the number of patients described in the literature is too small to draw any definite conclusions. Promising molecular biology studies are under way to evaluate the role of oncosuppresor gene expression in hepatocarcinogenesis and in the way the disease spreads.

Original languageEnglish
Pages (from-to)77-80
Number of pages4
JournalJournal of Neurosurgical Sciences
Volume46
Issue number2
Publication statusPublished - Jun 2002

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Hepatocellular Carcinoma
Neoplasm Metastasis
Brain
Liver Cirrhosis
Molecular Biology
Fibrosis
Radiotherapy
Stroke
Pathology
Gene Expression
Neoplasms

Keywords

  • Brain neoplasms, secondary
  • Genes, suppressor, tumor
  • Hepatitis B
  • Liver neoplasms, diagnosis
  • Magnetic resonance imaging
  • Tomography, X-ray computed

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Salvati, M., Cimatti, M., Frati, A., Santoro, A., Gagliardi, F. M., & Cucciniello, B. (2002). Brain metastases from hepatocellular carcinoma: A case report. Journal of Neurosurgical Sciences, 46(2), 77-80.

Brain metastases from hepatocellular carcinoma : A case report. / Salvati, M.; Cimatti, M.; Frati, A.; Santoro, A.; Gagliardi, F. M.; Cucciniello, B.

In: Journal of Neurosurgical Sciences, Vol. 46, No. 2, 06.2002, p. 77-80.

Research output: Contribution to journalArticle

Salvati, M, Cimatti, M, Frati, A, Santoro, A, Gagliardi, FM & Cucciniello, B 2002, 'Brain metastases from hepatocellular carcinoma: A case report', Journal of Neurosurgical Sciences, vol. 46, no. 2, pp. 77-80.
Salvati M, Cimatti M, Frati A, Santoro A, Gagliardi FM, Cucciniello B. Brain metastases from hepatocellular carcinoma: A case report. Journal of Neurosurgical Sciences. 2002 Jun;46(2):77-80.
Salvati, M. ; Cimatti, M. ; Frati, A. ; Santoro, A. ; Gagliardi, F. M. ; Cucciniello, B. / Brain metastases from hepatocellular carcinoma : A case report. In: Journal of Neurosurgical Sciences. 2002 ; Vol. 46, No. 2. pp. 77-80.
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