Brain metastases from solid tumors: Disease outcome according to type of treatment and therapeutic resources of the treating center

Alessandra Fabi, Alessandra Felici, Giulio Metro, Alessandra Mirri, Emilio Bria, Stefano Telera, Luca Moscetti, Michelangelo Russillo, Gaetano Lanzetta, Giovanni Mansueto, Andrea Pace, Marta Maschio, Antonello Vidiri, Isabella Sperduti, Francesco Cognetti, Carmine M. Carapella

Research output: Contribution to journalArticlepeer-review

Abstract

Background: To evaluate the therapeutic strategies commonly employed in the clinic for the management of brain metastases (BMs) and to correlate disease outcome with type of treatment and therapeutic resources available at the treating center. Methods. Four Cancer centres participated to the survey. Data were collected through a questionnaire filled in by one physician for each centre. Results: Clinical data regarding 290 cancer patients with BMs from solid tumors were collected. Median age was 59 and 59% of patients had 3 brain metastases. A local approach (surgery and stereotactic radiosurgery) was adopted in 31% of patients. The local approach demonstrated to be superior in terms of survival compared to the regional/systemic approach (whole brain radiotherapy and chemotherapy, p =

Original languageEnglish
Article number10
JournalJournal of Experimental and Clinical Cancer Research
Volume30
Issue number1
DOIs
Publication statusPublished - 2011

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

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