Brain metastases in patients with advanced breast cancer

Giuseppina Sanna, L. Franceschelli, N. Rotmensz, E. Botteri, L. Adamoli, C. Marenghi, E. Munzone, M. Cossu Rocca, E. Verri, I. Minchella, M. Medici, C. Catania, E. Magni, A. Goldhirsch, F. Nolè

Research output: Contribution to journalArticlepeer-review


Background: The incidence of brain metastases (BM) is apparently rising in patients with advanced breast cancer (ABC). We performed a case control study to define current features of breast cancer related to central nervous system (CNS) metastases. Patients and Methods: From March 1999 to May 2006, we identified 72 patients with symptomatic BM of breast cancer. A comparison group was randomly selected assigning to each case two patients with primary breast cancer and no BM, matched for year of diagnosis, age and tumour stage (pT status and nodal status). Results: Cases had a significantly higher rate of negative estrogen receptors (ERs) (60% in cases vs. 29% in controls), negative progesterone receptors (PgRs) (79% vs. 43%), HER2/neu over expression (44% vs. 13%) and immunostaining for Ki-67 ≥20% (84% vs. 55%), with p-value

Original languageEnglish
Pages (from-to)2865-2869
Number of pages5
JournalAnticancer Research
Issue number4 C
Publication statusPublished - Jul 2007


  • Advanced breast cancer
  • Brain metastases
  • Risk factors

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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