Brain metastases in patients with advanced breast cancer

Giuseppina Sanna; L. Franceschelli; N. Rotmensz; E. Botteri; L. Adamoli; C. Marenghi; E. Munzone; M. Cossu Rocca; E. Verri; I. Minchella; M. Medici; C. Catania; E. Magni; A. Goldhirsch; F. Nolè

Brain metastases in patients with advanced breast cancer

Giuseppina Sanna, L. Franceschelli, N. Rotmensz, E. Botteri, L. Adamoli, C. Marenghi, E. Munzone, M. Cossu Rocca, E. Verri, I. Minchella, M. Medici, C. Catania, E. Magni, A. Goldhirsch, F. Nolè

Research output: Contribution to journal › Article › peer-review

Abstract

Background: The incidence of brain metastases (BM) is apparently rising in patients with advanced breast cancer (ABC). We performed a case control study to define current features of breast cancer related to central nervous system (CNS) metastases. Patients and Methods: From March 1999 to May 2006, we identified 72 patients with symptomatic BM of breast cancer. A comparison group was randomly selected assigning to each case two patients with primary breast cancer and no BM, matched for year of diagnosis, age and tumour stage (pT status and nodal status). Results: Cases had a significantly higher rate of negative estrogen receptors (ERs) (60% in cases vs. 29% in controls), negative progesterone receptors (PgRs) (79% vs. 43%), HER2/neu over expression (44% vs. 13%) and immunostaining for Ki-67 ≥20% (84% vs. 55%), with p-value

Original language	English
Pages (from-to)	2865-2869
Number of pages	5
Journal	Anticancer Research
Volume	27
Issue number	4 C
Publication status	Published - Jul 2007

Keywords

Advanced breast cancer
Brain metastases
Risk factors

ASJC Scopus subject areas

Cancer Research
Oncology

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Brain metastases in patients with advanced breast cancer. / Sanna, Giuseppina; Franceschelli, L.; Rotmensz, N.; Botteri, E.; Adamoli, L.; Marenghi, C.; Munzone, E.; Cossu Rocca, M.; Verri, E.; Minchella, I.; Medici, M.; Catania, C.; Magni, E.; Goldhirsch, A.; Nolè, F.

In: Anticancer Research, Vol. 27, No. 4 C, 07.2007, p. 2865-2869.

Research output: Contribution to journal › Article › peer-review

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abstract = "Background: The incidence of brain metastases (BM) is apparently rising in patients with advanced breast cancer (ABC). We performed a case control study to define current features of breast cancer related to central nervous system (CNS) metastases. Patients and Methods: From March 1999 to May 2006, we identified 72 patients with symptomatic BM of breast cancer. A comparison group was randomly selected assigning to each case two patients with primary breast cancer and no BM, matched for year of diagnosis, age and tumour stage (pT status and nodal status). Results: Cases had a significantly higher rate of negative estrogen receptors (ERs) (60% in cases vs. 29% in controls), negative progesterone receptors (PgRs) (79% vs. 43%), HER2/neu over expression (44% vs. 13%) and immunostaining for Ki-67 ≥20% (84% vs. 55%), with p-value ",

keywords = "Advanced breast cancer, Brain metastases, Risk factors",

author = "Giuseppina Sanna and L. Franceschelli and N. Rotmensz and E. Botteri and L. Adamoli and C. Marenghi and E. Munzone and {Cossu Rocca}, M. and E. Verri and I. Minchella and M. Medici and C. Catania and E. Magni and A. Goldhirsch and F. Nol{\`e}",

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AU - Sanna, Giuseppina

AU - Franceschelli, L.

AU - Rotmensz, N.

AU - Botteri, E.

AU - Adamoli, L.

AU - Marenghi, C.

AU - Munzone, E.

AU - Cossu Rocca, M.

AU - Verri, E.

AU - Minchella, I.

AU - Medici, M.

AU - Catania, C.

AU - Magni, E.

AU - Goldhirsch, A.

AU - Nolè, F.

PY - 2007/7

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N2 - Background: The incidence of brain metastases (BM) is apparently rising in patients with advanced breast cancer (ABC). We performed a case control study to define current features of breast cancer related to central nervous system (CNS) metastases. Patients and Methods: From March 1999 to May 2006, we identified 72 patients with symptomatic BM of breast cancer. A comparison group was randomly selected assigning to each case two patients with primary breast cancer and no BM, matched for year of diagnosis, age and tumour stage (pT status and nodal status). Results: Cases had a significantly higher rate of negative estrogen receptors (ERs) (60% in cases vs. 29% in controls), negative progesterone receptors (PgRs) (79% vs. 43%), HER2/neu over expression (44% vs. 13%) and immunostaining for Ki-67 ≥20% (84% vs. 55%), with p-value

AB - Background: The incidence of brain metastases (BM) is apparently rising in patients with advanced breast cancer (ABC). We performed a case control study to define current features of breast cancer related to central nervous system (CNS) metastases. Patients and Methods: From March 1999 to May 2006, we identified 72 patients with symptomatic BM of breast cancer. A comparison group was randomly selected assigning to each case two patients with primary breast cancer and no BM, matched for year of diagnosis, age and tumour stage (pT status and nodal status). Results: Cases had a significantly higher rate of negative estrogen receptors (ERs) (60% in cases vs. 29% in controls), negative progesterone receptors (PgRs) (79% vs. 43%), HER2/neu over expression (44% vs. 13%) and immunostaining for Ki-67 ≥20% (84% vs. 55%), with p-value

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