@article{eb8136bd28244a8f9fcf24274fa0f9f8,
title = "Brain metastases in patients with EOC: Clinico-pathological and prognostic factors. A multicentric retrospective analysis from the MITO group (MITO 19)",
abstract = "Background Brain metastases (BM) from epithelial ovarian cancer (EOC) are considered a rare and unfavourable event. There is no consensus regarding the best management of these patients. Methods A multicenter retrospective analysis of patients with BM from EOC treated between 1997 and 2014 in 18 institutions of the MITO (Multicenter Italian Trials in Ovarian cancer) group was conducted. Univariate and multivariate analysis were performed. Results A total of 174 women were identified as having BM from EOC. The median time interval between primary diagnosis of EOC and occurrence of BM was 26 months (range 2–129 months). The median overall survival from primary EOC diagnosis was 48 months (95% CI 39.5–56.4 months) and from diagnosis of BM was 12 months (95% CI 9.6–14.3 months). The majority of enrolled women (81.7%) were classified as sensitive to platinum-based chemotherapy. Four variables were significantly associated with poor overall survival in multivariate analysis: multiple BM [HR: 1.86 (95% CI: 1.22–2.84)], presence of extracranial disease [HR: 1.77 (95% CI: 1.11–2.83)] age [HR: 1.74 (95% CI: 1.17–2.59)], and monotherapy [HR: 2.57 (95% CI: 1.64–3.86)]. On the contrary, residual tumor at primary surgery, FIGO stage at primary diagnosis and platinum sensitivity were found to have no significant impact on survival from diagnosis of brain lesions. Conclusions Our results suggest that BM is a rare and late manifestation of EOC, with a 12-month life-span expectation. Multiple approach is a positive independent prognostic factor and should be proposed to carefully selected patients. {\textcopyright} 2016",
keywords = "Brain metastasis, Ovarian cancer, Platinum sensitivity",
author = "C. Marchetti and Gabriella Ferrandina and G. Cormio and A. Gambino and S. Cecere and D. Lorusso and {De Giorgi}, U. and S. Bogliolo and Anna Fagotti and S. Mammoliti and Fabrice Narducci and Alice Bergamini and P. Scollo and N. Biglia and Enrico Breda and Stefano Tamberi and M. Marinaccio and Roberto Angioli and L. Salerno and Eusebi, {Maria Chiara} and V. Loizzi and G. Scambia and Panici, {P. L B}",
note = "Export Date: 16 March 2017 CODEN: GYNOA Correspondence Address: Marchetti, C.; Department of Gynecological and Obstetrical Sciences and Urological Sciences, University of Rome “Sapienza”, Viale del Policlinico 155, Italy; email: clamarchetti@libero.it References: Tosoni, A., Ermani, M., Brandes, A.A., The pathogenesis and treatment of brain metastases: a comprehensive review (2004) Crit. Rev. Oncol. Hematol., 52, pp. 199-215; Schouten, L.J., Rutten, J., Huveneers, H.A.M., Twijnstra, A., Incidence of brain metastases in a cohort of patients with carcinoma of the breast, colon, kidney, and lung and melanoma (2002) Cancer, 94, pp. 2698-2705; Kim, T.J., Song, S., Kim, C.K., Kim, W.Y., Choi, C.H., Lee, J.H., Lee, J.W., Kim, B.G., Prognostic factors associated with brain metastases from epithelial ovarian carcinoma (2007) Int. J. Gynecol. 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year = "2016",
doi = "10.1016/j.ygyno.2016.09.025",
language = "English",
volume = "143",
pages = "532--538",
journal = "Gynecologic Oncology",
issn = "0090-8258",
publisher = "Academic Press Inc.",
number = "3",
}