Brain metastasis from cutaneous squamous cell carcinoma of the dorsum

Maurizio Salvati, Emanuela Caroli, Cristina Paone, Alessandro Frati, Luigi Ferrante, Felice Giangaspero, Roberto Delfini

Research output: Contribution to journalArticlepeer-review


The majority of cutaneous squamous cell carcinoma (SCC) are diagnosed early and cured using local treatment, although a minority of cases metastasize to regional structures. In this report the authors describe an unknown feature of skin SCC, namely, distant brain metastasis. This 54-year-old man, who had undergone surgery for moderately differentiated SCC of the dorsum (T2N0M0 stage), was admitted to our institution 11 months later with headache, vomiting, and ataxia. A magnetic resonance image documented a cerebellar lesion, which was totally removed. Results of histological studies revealed SCC. The patient received whole-brain radiotherapy (30 Gy over 2 weeks using a linear accelerator). A metastatic work-up showed enlarged inguinal and para-aortic lymph nodes that were histologically examined using excisional biopsy. Inguinal lymph nodes were tumor-positive and were dissected. The patient was subjected to two cycles of chemotherapy with cisplatin (75 mg/m2). After 3 months, a significant reduction in the size of the para-aortic lymph nodes was documented on control computerized tomography studies. Although the described case is unique, knowledge of the potential for this uncommon behavior in cutaneous SCC may be useful, especially because of its increasing incidence.

Original languageEnglish
Pages (from-to)1155-1158
Number of pages4
JournalJournal of Neurosurgery
Issue number6
Publication statusPublished - Jun 2005


  • Brain metastasis
  • Dorsum
  • Skin
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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