Brain metastasis from hepatocellular carcinoma associated with hepatitis B virus

Alessandro Frati, M. Salvati, E. Giarnieri, A. Santoro, G. Rocchi, L. Frati

Research output: Contribution to journalArticle

Abstract

Four cases of brain metastasis from hepatocellular carcinoma (HCC) associated with hepatitis B virus (HBV) are reported in an area not endemic for HBV infection. Two cases are unusual, since cerebral metastases were the only secondary localization. In these cases, no other sites of metastasization were detected either before or immediately following neurosurgical treatment. In all cases the expression of pRB, p53 and p16 tumor suppressor protein was studied with immunohistochemistry, both, in the primary and metastatic lesions. The pRB expression was as follows: in two cases, lack and moderate expression were observed both, in the primary and in the metastases; in the other two, pRB was not detected. In all cases p 53 expression was negative both, in the primary and the metastases. P16 expression was moderately expressed in three cases, both in the primary and the metastases. In one case it was absent. Hepatocarcinogenesis is a multistep process, in which several oncogenes and oncosuppressor genes are involved. In four unusual cases of spread to the brain, we evidenced that tumor suppressor protein expression of p16, p53, and particularly pRB (its aberrated expression is usually associated with metastasis) were altered. We also suggest that HBV and its X protein (HBX) might play an important role in such aggressive behavior of the neoplasia.

Original languageEnglish
Pages (from-to)321-327
Number of pages7
JournalJournal of Experimental and Clinical Cancer Research
Volume21
Issue number3
Publication statusPublished - Sep 2002

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Keywords

  • Brain metastasis
  • Hepatitis B virus
  • Hepatocellular carcinoma
  • P16
  • P53
  • PRB

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Frati, A., Salvati, M., Giarnieri, E., Santoro, A., Rocchi, G., & Frati, L. (2002). Brain metastasis from hepatocellular carcinoma associated with hepatitis B virus. Journal of Experimental and Clinical Cancer Research, 21(3), 321-327.