Brain metastasis from prostate cancer. Report of 13 cases and critical analysis of the literature

Maurizio Salvati, A. Frati, N. Russo, C. Brogna, M. Piccirilli, G. D'Andrea, G. Occhiogrosso, A. Pichierri, E. Caroli

Research output: Contribution to journalArticle

Abstract

Brain metastasis from prostate carcinoma occurs very rarely. We describe 13 patients with single brain metastasis from prostatic cancer. Total removal of the lesions was performed in ten patients. Three patients underwent stereotactic biopsy. All patients were treated with postoperative whole brain radiotherapy (WBRT). Eight patients died for systemic disease after a mean time of 9.2 months with a diagnosis of metastasis. Five patients are still alive at 20, 14, 11,7 and 6 months, respectively. Even if brain metastasis from prostate cancer is often a terminal event with death occurring within few months from diagnosis, we suggest the same protocol (surgery and/or radiosurgery plus postoperative WBRT) usually adopted to treat brain metastasis from other primitive tumours. A non specific neurological symptomatology and a possible normal dosage of serum specific antigen may contribute to a delay in diagnosis. However, considering the rarity of brain metastasis from prostate carcinoma, standard brain MRI follow-up in men with prostatic cancer does not seem to be necessary yet.

Original languageEnglish
Pages (from-to)203-207
Number of pages5
JournalJournal of Experimental and Clinical Cancer Research
Volume24
Issue number2
Publication statusPublished - Jun 2005

Keywords

  • Brain metastasis
  • Prostatic carcinoma
  • Radiosurgery
  • Radiotherapy
  • Surgery

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Salvati, M., Frati, A., Russo, N., Brogna, C., Piccirilli, M., D'Andrea, G., Occhiogrosso, G., Pichierri, A., & Caroli, E. (2005). Brain metastasis from prostate cancer. Report of 13 cases and critical analysis of the literature. Journal of Experimental and Clinical Cancer Research, 24(2), 203-207.