Abstract
Brain morphology was evaluated by means of Magnetic Resonance Imaging (MRI) in 8 sib-pairs discordant for schizophrenia. The experimental approach of evaluating brain morphology in sib-pairs permitted to reduce neuromorphological variability (connected to genetic and environmental factors) between patients and controls; moreover, the use of a MRI acquisition protocol, image analysis and segmentation software developed on purpose allowed us to differentiate between gray and white matter volumes. Results, though preliminary, confirm the well established evidence of lateral ventricular enlargement in schizophrenia, and show a volumetric reduction of gray and white matter of frontal and temporal lobes. Besides, our results suggest that even if brain morphological abnormalities in course of schizophrenia are slight, they can be detected in a large number of patients.
| Original language | English |
|---|---|
| Pages (from-to) | 41-45 |
| Number of pages | 5 |
| Journal | New Trends in Experimental and Clinical Psychiatry |
| Volume | 15 |
| Issue number | 1 |
| Publication status | Published - 1999 |
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Keywords
- Brain morphology
- MRI
- Schizophrenia
- Sib-pairs
ASJC Scopus subject areas
- Psychiatry and Mental health
Cite this
Brain morphology in sib-pairs discordant for schizophrenia : Preliminary results from a MRI quantitative study. / Dieci, M.; Tenconi, F.; Ferri, S.; Bettinardi, V.; Righini, A.; Bettinelli, A.; De Peri, L.; Vita, A.; Invernizzi, G.
In: New Trends in Experimental and Clinical Psychiatry, Vol. 15, No. 1, 1999, p. 41-45.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Brain morphology in sib-pairs discordant for schizophrenia
T2 - Preliminary results from a MRI quantitative study
AU - Dieci, M.
AU - Tenconi, F.
AU - Ferri, S.
AU - Bettinardi, V.
AU - Righini, A.
AU - Bettinelli, A.
AU - De Peri, L.
AU - Vita, A.
AU - Invernizzi, G.
PY - 1999
Y1 - 1999
N2 - Brain morphology was evaluated by means of Magnetic Resonance Imaging (MRI) in 8 sib-pairs discordant for schizophrenia. The experimental approach of evaluating brain morphology in sib-pairs permitted to reduce neuromorphological variability (connected to genetic and environmental factors) between patients and controls; moreover, the use of a MRI acquisition protocol, image analysis and segmentation software developed on purpose allowed us to differentiate between gray and white matter volumes. Results, though preliminary, confirm the well established evidence of lateral ventricular enlargement in schizophrenia, and show a volumetric reduction of gray and white matter of frontal and temporal lobes. Besides, our results suggest that even if brain morphological abnormalities in course of schizophrenia are slight, they can be detected in a large number of patients.
AB - Brain morphology was evaluated by means of Magnetic Resonance Imaging (MRI) in 8 sib-pairs discordant for schizophrenia. The experimental approach of evaluating brain morphology in sib-pairs permitted to reduce neuromorphological variability (connected to genetic and environmental factors) between patients and controls; moreover, the use of a MRI acquisition protocol, image analysis and segmentation software developed on purpose allowed us to differentiate between gray and white matter volumes. Results, though preliminary, confirm the well established evidence of lateral ventricular enlargement in schizophrenia, and show a volumetric reduction of gray and white matter of frontal and temporal lobes. Besides, our results suggest that even if brain morphological abnormalities in course of schizophrenia are slight, they can be detected in a large number of patients.
KW - Brain morphology
KW - MRI
KW - Schizophrenia
KW - Sib-pairs
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M3 - Article
AN - SCOPUS:0033033969
VL - 15
SP - 41
EP - 45
JO - New Trends in Experimental and Clinical Psychiatry
JF - New Trends in Experimental and Clinical Psychiatry
SN - 0393-5310
IS - 1
ER -