Brain morphology in sib-pairs discordant for schizophrenia: Preliminary results from a MRI quantitative study

M. Dieci, F. Tenconi, S. Ferri, V. Bettinardi, A. Righini, A. Bettinelli, L. De Peri, A. Vita, G. Invernizzi

Research output: Contribution to journalArticlepeer-review

Abstract

Brain morphology was evaluated by means of Magnetic Resonance Imaging (MRI) in 8 sib-pairs discordant for schizophrenia. The experimental approach of evaluating brain morphology in sib-pairs permitted to reduce neuromorphological variability (connected to genetic and environmental factors) between patients and controls; moreover, the use of a MRI acquisition protocol, image analysis and segmentation software developed on purpose allowed us to differentiate between gray and white matter volumes. Results, though preliminary, confirm the well established evidence of lateral ventricular enlargement in schizophrenia, and show a volumetric reduction of gray and white matter of frontal and temporal lobes. Besides, our results suggest that even if brain morphological abnormalities in course of schizophrenia are slight, they can be detected in a large number of patients.

Original languageEnglish
Pages (from-to)41-45
Number of pages5
JournalNew Trends in Experimental and Clinical Psychiatry
Volume15
Issue number1
Publication statusPublished - 1999

Keywords

  • Brain morphology
  • MRI
  • Schizophrenia
  • Sib-pairs

ASJC Scopus subject areas

  • Psychiatry and Mental health

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