Brain MR imaging in patients with lower motor neuron-predominant disease

Edoardo G. Spinelli, Federica Agosta, Pilar M. Ferraro, Nilo Riva, Christian Lunetta, Yuri M. Falzone, Giancarlo Comi, Andrea Falini, Massimo Filippi

Research output: Contribution to journalArticlepeer-review


Purpose: To investigate the patterns of cortical thinning and white matter tract damage in patients with lower motor neuron (LMN)-predominant disease compared with healthy control subjects and those with classic amyotrophic lateral sclerosis (ALS) and to evaluate the relationship between brain structural changes and clinical and cognitive features in these patients. Materials and Methods: This study was approved by the local ethical committee, and written informed consent was obtained from all subjects before enrollment. Twenty-eight patients with LMNpredominant disease were compared with 55 patients with ALS and 56 healthy control subjects. Patients underwent a clinical and neuropsychological assessment and T1-weighted and diffusion-tensor magnetic resonance (MR) imaging. Surface-based morphometry was used to assess cortical thickness. Tract-based spatial statistics and tractography were used to study white matter tract damage. Results: Patients with LMN-predominant disease did not show differences compared with healthy control subjects in cortical thickness and diffusion-tensor MR imaging metrics. Patients with ALS showed cortical thinning of the motor-related cortices and a distributed involvement of the prefrontal, temporal, and parietal gyri (P

Original languageEnglish
Pages (from-to)545-556
Number of pages12
Issue number2
Publication statusPublished - Aug 1 2016

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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