Brain MRI diffusion-weighted imaging in patients with classical phenylketonuria

Renzo Manara, Alessandro P. Burlina, Valentina Citton, Mario Ermani, Francesco Vespignani, Carla Carollo, Alberto B. Burlina

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Abstract

Introduction: The aim of this study was to grade magnetic resonance white matter abnormalities (WMAs) of classical phenylketonuria (cPKU) patients treated from birth and to compare sensitivity and specificity of T2-weighted and diffusion-weighted images (DWI). Methods: Twenty early-treated cPKU patients still on a low-phenylalanine diet (12 males; mean age 21.2 years) and 26 normal subjects (ten males; mean age 25.1 years) were enrolled. Typical T2- and diffusion-weighted WMAs were semiquantitatively graded according to Thompson score (TS). Besides, a regional magnetic resonance imaging (MRI) score (mTS) was developed according to extension and intensity of WMAs. Phenylalanine and tyrosine plasma concentrations before performing MRI and the amino acid mean levels collected the year before MRI (Tyryear and Pheyear) were measured. Results: No patient with Pheyear concentration below 460 μmol/L showed WMAs. In cPKU patients, TS and mTS were significantly higher on DWI than on T2 images (3.50 vs 2.65 and 23.65 vs 15.85, respectively, p <0.002, Wilcoxon test). All controls were scored 0 on DWI, while in T2 images, TS and mTS were 0.19 and 1.70. DWI evaluated by mTS disclosed a frontotemporal, occipital, and parietal WM progressive involvement. TS and mTS, both on T2 images and on DWI, showed no correlation with tyrosine while they proved to have a strong correlation with phenylalaninemia and an excellent one with Pheyear levels. Conclusion: Among the different MR sequences, DWI seems to be the most sensitive and reliable in detecting and grading the typical WMAs of cPKU patients.

Original languageEnglish
Pages (from-to)803-812
Number of pages10
JournalNeuroradiology
Volume51
Issue number12
DOIs
Publication statusPublished - Dec 2009

Fingerprint

Phenylketonurias
Diffusion Magnetic Resonance Imaging
Brain
Magnetic Resonance Imaging
Phenylalanine
Tyrosine
Magnetic Resonance Spectroscopy
White Matter
Parturition
Diet
Amino Acids
Sensitivity and Specificity

Keywords

  • Diffusion-weighted imaging
  • Magnetic resonance imaging
  • Metabolic disease
  • Phenylketonuria

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Manara, R., Burlina, A. P., Citton, V., Ermani, M., Vespignani, F., Carollo, C., & Burlina, A. B. (2009). Brain MRI diffusion-weighted imaging in patients with classical phenylketonuria. Neuroradiology, 51(12), 803-812. https://doi.org/10.1007/s00234-009-0574-z

Brain MRI diffusion-weighted imaging in patients with classical phenylketonuria. / Manara, Renzo; Burlina, Alessandro P.; Citton, Valentina; Ermani, Mario; Vespignani, Francesco; Carollo, Carla; Burlina, Alberto B.

In: Neuroradiology, Vol. 51, No. 12, 12.2009, p. 803-812.

Research output: Contribution to journalArticle

Manara, R, Burlina, AP, Citton, V, Ermani, M, Vespignani, F, Carollo, C & Burlina, AB 2009, 'Brain MRI diffusion-weighted imaging in patients with classical phenylketonuria', Neuroradiology, vol. 51, no. 12, pp. 803-812. https://doi.org/10.1007/s00234-009-0574-z
Manara R, Burlina AP, Citton V, Ermani M, Vespignani F, Carollo C et al. Brain MRI diffusion-weighted imaging in patients with classical phenylketonuria. Neuroradiology. 2009 Dec;51(12):803-812. https://doi.org/10.1007/s00234-009-0574-z
Manara, Renzo ; Burlina, Alessandro P. ; Citton, Valentina ; Ermani, Mario ; Vespignani, Francesco ; Carollo, Carla ; Burlina, Alberto B. / Brain MRI diffusion-weighted imaging in patients with classical phenylketonuria. In: Neuroradiology. 2009 ; Vol. 51, No. 12. pp. 803-812.
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