Brain natriuretic peptide in acute myocardial infarction: a marker of cardio-renal interaction

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Abstract

AIMS: Cardiac and renal functions are major independent predictors of outcomes in both ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation myocardial infarction (NSTEMI). As B-type natriuretic peptide (BNP) seems to be a major mediator in the cross-talk between heart and kidneys, we aimed at evaluating its capacity to reflect cardiac and renal function in patients with STEMI and NSTEMI. METHODS: We measured BNP plasma levels at hospital admission in 619 patients with STEMI (n?=?346) and NSTEMI (n?=?273), grouped according to left ventricular ejection fraction (LVEF; > or ≤40%) and estimated glomerular filtration rate (eGFR; > or ≤?60 ml/min/1.73?m). RESULTS: Median BNP values were 82 (38–186), 121 (40–342), 219 (80–685), and 474 (124–1263) pg/ml in patients with normal LVEF and eGFR (n?=?347), with LVEF 40% or less and eGFR higher than 60?ml/min/1.73?m (n?=?120), with LVEF higher than 40% and eGFR 60 ml/min/1.73?m or less (n?=?86), and with combined LVEF and eGFR reductions (n?=?66), respectively (P?

Original languageEnglish
JournalJournal of Cardiovascular Medicine
DOIs
Publication statusAccepted/In press - Jan 18 2016

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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