Brain natriuretic peptide in acute myocardial infarction

a marker of cardio-renal interaction

Research output: Contribution to journalArticle

Abstract

AIMS: Cardiac and renal functions are major independent predictors of outcomes in both ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation myocardial infarction (NSTEMI). As B-type natriuretic peptide (BNP) seems to be a major mediator in the cross-talk between heart and kidneys, we aimed at evaluating its capacity to reflect cardiac and renal function in patients with STEMI and NSTEMI. METHODS: We measured BNP plasma levels at hospital admission in 619 patients with STEMI (n?=?346) and NSTEMI (n?=?273), grouped according to left ventricular ejection fraction (LVEF; > or ≤40%) and estimated glomerular filtration rate (eGFR; > or ≤?60 ml/min/1.73?m). RESULTS: Median BNP values were 82 (38–186), 121 (40–342), 219 (80–685), and 474 (124–1263) pg/ml in patients with normal LVEF and eGFR (n?=?347), with LVEF 40% or less and eGFR higher than 60?ml/min/1.73?m (n?=?120), with LVEF higher than 40% and eGFR 60 ml/min/1.73?m or less (n?=?86), and with combined LVEF and eGFR reductions (n?=?66), respectively (P?

Original languageEnglish
JournalJournal of Cardiovascular Medicine
DOIs
Publication statusAccepted/In press - Jan 18 2016

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Brain Natriuretic Peptide
Myocardial Infarction
Kidney
Glomerular Filtration Rate
Stroke Volume
Non-ST Elevated Myocardial Infarction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

@article{74294cadce064f11aeb01efb617f5767,
title = "Brain natriuretic peptide in acute myocardial infarction: a marker of cardio-renal interaction",
abstract = "AIMS: Cardiac and renal functions are major independent predictors of outcomes in both ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation myocardial infarction (NSTEMI). As B-type natriuretic peptide (BNP) seems to be a major mediator in the cross-talk between heart and kidneys, we aimed at evaluating its capacity to reflect cardiac and renal function in patients with STEMI and NSTEMI. METHODS: We measured BNP plasma levels at hospital admission in 619 patients with STEMI (n?=?346) and NSTEMI (n?=?273), grouped according to left ventricular ejection fraction (LVEF; > or ≤40{\%}) and estimated glomerular filtration rate (eGFR; > or ≤?60 ml/min/1.73?m). RESULTS: Median BNP values were 82 (38–186), 121 (40–342), 219 (80–685), and 474 (124–1263) pg/ml in patients with normal LVEF and eGFR (n?=?347), with LVEF 40{\%} or less and eGFR higher than 60?ml/min/1.73?m (n?=?120), with LVEF higher than 40{\%} and eGFR 60 ml/min/1.73?m or less (n?=?86), and with combined LVEF and eGFR reductions (n?=?66), respectively (P?",
author = "Marco Moltrasio and Nicola Cosentino and {de Metrio}, Monica and Mara Rubino and Angelo Cabiati and Valentina Milazzo and Andrea Discacciati and Ivana Marana and Alice Bonomi and Fabrizio Veglia and Gianfranco Lauri and Giancarlo Marenzi",
year = "2016",
month = "1",
day = "18",
doi = "10.2459/JCM.0000000000000353",
language = "English",
journal = "Journal of Cardiovascular Medicine",
issn = "1558-2027",
publisher = "Lippincott Williams and Wilkins",

}

TY - JOUR

T1 - Brain natriuretic peptide in acute myocardial infarction

T2 - a marker of cardio-renal interaction

AU - Moltrasio, Marco

AU - Cosentino, Nicola

AU - de Metrio, Monica

AU - Rubino, Mara

AU - Cabiati, Angelo

AU - Milazzo, Valentina

AU - Discacciati, Andrea

AU - Marana, Ivana

AU - Bonomi, Alice

AU - Veglia, Fabrizio

AU - Lauri, Gianfranco

AU - Marenzi, Giancarlo

PY - 2016/1/18

Y1 - 2016/1/18

N2 - AIMS: Cardiac and renal functions are major independent predictors of outcomes in both ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation myocardial infarction (NSTEMI). As B-type natriuretic peptide (BNP) seems to be a major mediator in the cross-talk between heart and kidneys, we aimed at evaluating its capacity to reflect cardiac and renal function in patients with STEMI and NSTEMI. METHODS: We measured BNP plasma levels at hospital admission in 619 patients with STEMI (n?=?346) and NSTEMI (n?=?273), grouped according to left ventricular ejection fraction (LVEF; > or ≤40%) and estimated glomerular filtration rate (eGFR; > or ≤?60 ml/min/1.73?m). RESULTS: Median BNP values were 82 (38–186), 121 (40–342), 219 (80–685), and 474 (124–1263) pg/ml in patients with normal LVEF and eGFR (n?=?347), with LVEF 40% or less and eGFR higher than 60?ml/min/1.73?m (n?=?120), with LVEF higher than 40% and eGFR 60 ml/min/1.73?m or less (n?=?86), and with combined LVEF and eGFR reductions (n?=?66), respectively (P?

AB - AIMS: Cardiac and renal functions are major independent predictors of outcomes in both ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation myocardial infarction (NSTEMI). As B-type natriuretic peptide (BNP) seems to be a major mediator in the cross-talk between heart and kidneys, we aimed at evaluating its capacity to reflect cardiac and renal function in patients with STEMI and NSTEMI. METHODS: We measured BNP plasma levels at hospital admission in 619 patients with STEMI (n?=?346) and NSTEMI (n?=?273), grouped according to left ventricular ejection fraction (LVEF; > or ≤40%) and estimated glomerular filtration rate (eGFR; > or ≤?60 ml/min/1.73?m). RESULTS: Median BNP values were 82 (38–186), 121 (40–342), 219 (80–685), and 474 (124–1263) pg/ml in patients with normal LVEF and eGFR (n?=?347), with LVEF 40% or less and eGFR higher than 60?ml/min/1.73?m (n?=?120), with LVEF higher than 40% and eGFR 60 ml/min/1.73?m or less (n?=?86), and with combined LVEF and eGFR reductions (n?=?66), respectively (P?

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