Brain natriuretic peptide is removed by continuous veno-venous hemofiltration in pediatric patients

Zaccaria Ricci, Cristiana Garisto, Stefano Morelli, Luca Di Chiara, Claudio Ronco, Sergio Picardo

Research output: Contribution to journalArticlepeer-review


We wanted to evaluate if brain natriuretic peptide (BNP) is cleared during continuous veno-venous hemofiltration (CVVH) sessions in children with congenital heart disease. A prospective observational single-center study was conducted in a post-cardiac surgery intensive care unit of the city children's hospital. Ten children requiring CVVH for acute kidney injury following cardiac surgery were enrolled. Seven of them were undergoing postoperative extracorporeal membrane oxygenation. BNP clearance was evaluated by the difference between pre-filter and post-filter BNP blood amount indexed to pre-filter BNP concentration. All CVVH treatments were performed with 0.6 m2 polyacrylonitrile filter, in predilution setting, at a dose of 80 mlykgyh. Troponin I and myoglobin levels were also measured and CVVH clearances of these markers calculated for comparison with BNP. A significant decrease in post-filter compared with pre-filter levels of BNP was shown in all 10 cases (P0.05) and their clearance was significantly lower than BNP (P: 0.0004). A daily analysis of BNP levels showed a significant decrease of its blood concentration. BNP levels were significantly reduced after three and four days from CVVH start (P

Original languageEnglish
Pages (from-to)33-36
Number of pages4
JournalInteractive Cardiovascular and Thoracic Surgery
Issue number1
Publication statusPublished - Jul 2009


  • Brain natriuretic peptide
  • Congenital heart disease
  • Continuous veno-venous hemofiltration
  • Pediatric cardiac surgery

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine
  • Surgery


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