Brain networks underlining verbal fluency decline during STN-DBS in Parkinson's disease: An ECD-SPECT study

Roberto Cilia, Chiara Siri, Giorgio Marotta, Danilo De Gaspari, Andrea Landi, Claudio B. Mariani, Riccardo Benti, Ioannis U. Isaias, Francesco Vergani, Gianni Pezzoli, Angelo Antonini

Research output: Contribution to journalArticlepeer-review

Abstract

We prospectively evaluated 20 patients with Parkinson's disease (PD) preoperatively and 12 months after subthalamic nucleus-deep brain stimulation (STN-DBS). All patients had clinical (UPDRS III) and neuropsychological evaluations as well as brain perfusion SPECT-ECD. Clinical and cognitive data were compared with 12 matched PD patients who had not undergone surgery. STN-DBS patients improved in motor symptoms and reduced medications but selectively declined in category fluency (p

Original languageEnglish
Pages (from-to)290-294
Number of pages5
JournalParkinsonism and Related Disorders
Volume13
Issue number5
DOIs
Publication statusPublished - Jul 2007

Keywords

  • Cerebral blood flow
  • Deep brain stimulation
  • Parkinson's disease
  • Subthalamic nucleus
  • Verbal fluency

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Neurology

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