Brain networks underlining verbal fluency decline during STN-DBS in Parkinson's disease

An ECD-SPECT study

Roberto Cilia, Chiara Siri, Giorgio Marotta, Danilo De Gaspari, Andrea Landi, Claudio B. Mariani, Riccardo Benti, Ioannis U. Isaias, Francesco Vergani, Gianni Pezzoli, Angelo Antonini

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

We prospectively evaluated 20 patients with Parkinson's disease (PD) preoperatively and 12 months after subthalamic nucleus-deep brain stimulation (STN-DBS). All patients had clinical (UPDRS III) and neuropsychological evaluations as well as brain perfusion SPECT-ECD. Clinical and cognitive data were compared with 12 matched PD patients who had not undergone surgery. STN-DBS patients improved in motor symptoms and reduced medications but selectively declined in category fluency (p

Original languageEnglish
Pages (from-to)290-294
Number of pages5
JournalParkinsonism and Related Disorders
Volume13
Issue number5
DOIs
Publication statusPublished - Jul 2007

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Subthalamic Nucleus
Deep Brain Stimulation
Single-Photon Emission-Computed Tomography
Parkinson Disease
Brain
Perfusion
Parkinson Disease 12

Keywords

  • Cerebral blood flow
  • Deep brain stimulation
  • Parkinson's disease
  • Subthalamic nucleus
  • Verbal fluency

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Neurology

Cite this

Brain networks underlining verbal fluency decline during STN-DBS in Parkinson's disease : An ECD-SPECT study. / Cilia, Roberto; Siri, Chiara; Marotta, Giorgio; Gaspari, Danilo De; Landi, Andrea; Mariani, Claudio B.; Benti, Riccardo; Isaias, Ioannis U.; Vergani, Francesco; Pezzoli, Gianni; Antonini, Angelo.

In: Parkinsonism and Related Disorders, Vol. 13, No. 5, 07.2007, p. 290-294.

Research output: Contribution to journalArticle

Cilia, R, Siri, C, Marotta, G, Gaspari, DD, Landi, A, Mariani, CB, Benti, R, Isaias, IU, Vergani, F, Pezzoli, G & Antonini, A 2007, 'Brain networks underlining verbal fluency decline during STN-DBS in Parkinson's disease: An ECD-SPECT study', Parkinsonism and Related Disorders, vol. 13, no. 5, pp. 290-294. https://doi.org/10.1016/j.parkreldis.2006.11.011
Cilia, Roberto ; Siri, Chiara ; Marotta, Giorgio ; Gaspari, Danilo De ; Landi, Andrea ; Mariani, Claudio B. ; Benti, Riccardo ; Isaias, Ioannis U. ; Vergani, Francesco ; Pezzoli, Gianni ; Antonini, Angelo. / Brain networks underlining verbal fluency decline during STN-DBS in Parkinson's disease : An ECD-SPECT study. In: Parkinsonism and Related Disorders. 2007 ; Vol. 13, No. 5. pp. 290-294.
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