Brain neurotransmitter systems and chronic lead intoxication

S. Govoni, M. Memo, L. Lucchi, P. F. Spano, M. Trabucchi

Research output: Contribution to journalArticlepeer-review


The neurotoxic effect of lead has been studied measuring the function of different neurotransmitters in various rat brain areas. Dopaminergic and GABAergic systems are modified at various steps: both at presynaptic and postsvnaptic (receptors) levels. The changes observed, together with those related with other brain neurotransmitters, suggest the hypothesis that the behavioural and clinical changes observed in humans exposed to lead may be explained on the bases of selective actions of lead on neurotransmitters in discrete brain areas.

Original languageEnglish
Pages (from-to)447-460
Number of pages14
JournalPharmacological Research Communications
Issue number5
Publication statusPublished - 1980

ASJC Scopus subject areas

  • Pharmacology


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