Brain neurotransmitter systems and chronic lead intoxication

S. Govoni, M. Memo, L. Lucchi, P. F. Spano, M. Trabucchi

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The neurotoxic effect of lead has been studied measuring the function of different neurotransmitters in various rat brain areas. Dopaminergic and GABAergic systems are modified at various steps: both at presynaptic and postsvnaptic (receptors) levels. The changes observed, together with those related with other brain neurotransmitters, suggest the hypothesis that the behavioural and clinical changes observed in humans exposed to lead may be explained on the bases of selective actions of lead on neurotransmitters in discrete brain areas.

Original languageEnglish
Pages (from-to)447-460
Number of pages14
JournalPharmacological Research Communications
Volume12
Issue number5
DOIs
Publication statusPublished - 1980

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Neurotransmitter Agents
Brain
Presynaptic Receptors
Lead

ASJC Scopus subject areas

  • Pharmacology

Cite this

Brain neurotransmitter systems and chronic lead intoxication. / Govoni, S.; Memo, M.; Lucchi, L.; Spano, P. F.; Trabucchi, M.

In: Pharmacological Research Communications, Vol. 12, No. 5, 1980, p. 447-460.

Research output: Contribution to journalArticle

Govoni, S, Memo, M, Lucchi, L, Spano, PF & Trabucchi, M 1980, 'Brain neurotransmitter systems and chronic lead intoxication', Pharmacological Research Communications, vol. 12, no. 5, pp. 447-460. https://doi.org/10.1016/S0031-6989(80)80115-9
Govoni, S. ; Memo, M. ; Lucchi, L. ; Spano, P. F. ; Trabucchi, M. / Brain neurotransmitter systems and chronic lead intoxication. In: Pharmacological Research Communications. 1980 ; Vol. 12, No. 5. pp. 447-460.
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