Brain perfusion correlates of cognitive and nigrostriatal functions in de novo Parkinson's disease

Flavio Nobili, Dario Arnaldi, Claudio Campus, Michela Ferrara, Fabrizio De Carli, Andrea Brugnolo, Barbara Dessi, Nicola Girtler, Silvia Morbelli, Giovanni Abruzzese, Gianmario Sambuceti, Guido Rodriguez

Research output: Contribution to journalArticlepeer-review


Purpose: Subtle cognitive impairment is recognized in the first stages of Parkinson's disease (PD), including executive, memory and visuospatial dysfunction, but its pathophysiological basis is still debated. Methods: Twenty-six consecutive, drug-naïve, de novo PD patients underwent an extended neuropsychological battery, dopamine transporter (DAT) and brain perfusion single photon emission computed tomography (SPECT). We previously reported that nigrocaudate impairment correlates with executive functions, and nigroputaminal impairment with visuospatial abilities. Here perfusion SPECT was first compared between the PD group and age-matched controls (CTR). Then, perfusion SPECTwas correlated with both DAT SPECT and four neuropsychological factors by means of voxel-based analysis (SPM8) with a height threshold of p

Original languageEnglish
Pages (from-to)2209-2218
Number of pages10
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Issue number12
Publication statusPublished - Dec 2011


  • Cognition
  • Neuropsychological assessment
  • Parkinson's disease
  • Perfusion SPECT

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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