Brain plasticity effects of neuromodulation against multiple sclerosis fatigue

Franca Tecchio, Andrea Cancelli, Carlo Cottone, Roberta Ferrucci, Maurizio Vergari, Giancarlo Zito, Patrizio Pasqualetti, Maria Maddalena Filippi, Anna Ghazaryan, Domenico Lupoi, Fenne M. Smits, Alessandro Giordani, Simone Migliore, Camillo Porcaro, Carlo Salustri, Paolo M. Rossini, Alberto Priori

Research output: Contribution to journalArticlepeer-review


Rationale: We recently reported on the efficacy of a personalized transcranial direct current stimulation (tDCS) treatment in reducing multiple sclerosis (MS) fatigue. The result supports the notion that interventions targeted at modifying abnormal excitability within the sensorimotor network could represent valid non-pharmacological treatments. Objective: The present work aimed at assessing whether the mentioned intervention also induces changes in the excitability of sensorimotor cortical areas. Method: Two separate groups of fatigued MS patients were given a 5-day tDCS treatments targeting, respectively, the whole body somatosensory areas (S1wb) and the hand sensorimotor areas (SM1hand). The study had a double blind, sham-controlled, randomized, cross-over (Real vs. Sham) design. Before and after each treatment, we measured fatigue levels (by the modified fatigue impact scale, mFIS), motor evoked potentials (MEPs) in response to transcranial magnetic stimulation and somatosensory evoked potentials (SEPs) in response to median nerve stimulation. We took MEPs and SEPs as measures of the excitability of the primary motor area (M1) and the primary somatosensory area (S1), respectively. Results: The Real S1wb treatment produced a 27% reduction of the mFIS baseline level, while the SM1hand treatment showed no difference between Real and Sham stimulations. M1 excitability increased on average 6% of the baseline in the S1wb group and 40% in the SM1hand group. Observed SEP changes were not significant and we found no association between M1 excitability changes and mFIS decrease. Conclusion: The tDCS treatment was more effective against MS fatigue when the electrode was focused on the bilateral whole body somatosensory area. Changes in S1 and M1 excitability did not correlate with symptoms amelioration. Significance: The neuromodulation treatment that proved effective against MS fatigue induced only minor variations of the motor cortex excitability, not enough to explain the beneficial effects of the intervention.

Original languageEnglish
Article number141
JournalFrontiers in Neurology
Issue numberJUL
Publication statusPublished - 2015


  • Electrode personalization
  • Electroencephalography
  • Fatigue in multiple sclerosis
  • Magnetic resonance imaging
  • Transcranial direct current stimulation
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology


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