Brain reactions to the use of sensorized hand prosthesis in amputees

Giuseppe Granata, Riccardo Di Iorio, Francesca Miraglia, Massimo Caulo, Francesco Iodice, Fabrizio Vecchio, Giacomo Valle, Ivo Strauss, Edoardo D'anna, Francesco Iberite, Liverana Lauretti, Eduardo Fernandez, Roberto Romanello, Francesco M. Petrini, Stanisa Raspopovic, Silvestro Micera, Paolo M. Rossini

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: We investigated for the first time the presence of chronic changes in the functional organization of sensorimotor brain areas induced by prolonged training with a bidirectional hand prosthesis. Methods: A multimodal neurophysiological and neuroimaging evaluation of brain functional changes occurring during training in five consecutive amputees participating to experimental trials with robotic hands over a period of 10 years was carried out. In particular, modifications to the functional anatomy of sensorimotor brain areas under resting conditions were explored in order to check for eventual changes with respect to baseline. Results: Full evidence is provided to demonstrate brain functional changes, and some of them in both the hemispheres and others restricted to the hemisphere contralateral to the amputation/prosthetic hand. Conclusions: The study describes a unique experimental experience showing that brain reactions to the prolonged use of an artificial hand can be tracked for a tailored approach to a fully embedded artificial upper limb for future chronic uses in daily activities.

Original languageEnglish
Article numbere01734
JournalBrain and Behavior
Volume10
Issue number11
DOIs
Publication statusPublished - Nov 2020

Keywords

  • advanced biotechnologies
  • brain function
  • hand prosthesis
  • personalized medicine

ASJC Scopus subject areas

  • Behavioral Neuroscience

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