@article{329dfc1abc994b4cab0b9ca2e563650d,
title = "Brain reactions to the use of sensorized hand prosthesis in amputees",
abstract = "Objective: We investigated for the first time the presence of chronic changes in the functional organization of sensorimotor brain areas induced by prolonged training with a bidirectional hand prosthesis. Methods: A multimodal neurophysiological and neuroimaging evaluation of brain functional changes occurring during training in five consecutive amputees participating to experimental trials with robotic hands over a period of 10 years was carried out. In particular, modifications to the functional anatomy of sensorimotor brain areas under resting conditions were explored in order to check for eventual changes with respect to baseline. Results: Full evidence is provided to demonstrate brain functional changes, and some of them in both the hemispheres and others restricted to the hemisphere contralateral to the amputation/prosthetic hand. Conclusions: The study describes a unique experimental experience showing that brain reactions to the prolonged use of an artificial hand can be tracked for a tailored approach to a fully embedded artificial upper limb for future chronic uses in daily activities.",
keywords = "advanced biotechnologies, brain function, hand prosthesis, personalized medicine",
author = "Giuseppe Granata and {Di Iorio}, Riccardo and Francesca Miraglia and Massimo Caulo and Francesco Iodice and Fabrizio Vecchio and Giacomo Valle and Ivo Strauss and Edoardo D'anna and Francesco Iberite and Liverana Lauretti and Eduardo Fernandez and Roberto Romanello and Petrini, {Francesco M.} and Stanisa Raspopovic and Silvestro Micera and Rossini, {Paolo M.}",
note = "Funding Information: The study was supported by three funded European and Italian projects: FP7-ICT-2013 (FET Proactive: Evolving Living Technologies) NEBIAS Project (?Neurocontrolled Bidirectional Artificial upper limb and hand prosthesis{"}) (Grant Agreement no. 611687). Partly funded by the Bertarelli Foundation, the Swiss National Competence Center Research (NCCR) Robotics, and by the CHRONOS project funded by the Swiss National Science Foundation. FP7-HEALTH-2013 (INNOVATION-1) EPIONE Project (?Natural sensory feedback for phantom limb pain modulation and therapy?) NEMESIS (NEurocontrolled MEchatronic prostheSIS) from the Italian Ministry of Health, 2013. We thank Dr. Laura Taormina, Dr. Rossana Moroni, and Dr. Emanuela Ricci for their important organizational role. Publisher Copyright: {\textcopyright} 2020 The Authors. Brain and Behavior published by Wiley Periodicals LLC. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",
year = "2020",
month = nov,
doi = "10.1002/brb3.1734",
language = "English",
volume = "10",
journal = "Brain and Behavior",
issn = "2157-9032",
publisher = "John Wiley and Sons Ltd",
number = "11",
}