Brain regional distribution pattern of metabolite signal intensities in young adults by proton magnetic resonance spectroscopic imaging

Gioacchino Tedeschi, A. Bertolino, A. Righini, G. Campbell, R. Raman, J. H. Duyn, C. T W Moonen, J. R. Alger, G. Di Chiro

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Abstract

Proton magnetic resonance spectroscopy (1 H-MRS) is evolving from single-volume localized acquisitions to multiple-volume acquisitions using magnetic resonance spectroscopic imaging (lH-MRSI). The normal regional patterns of 1H-MRSI-detectable metabolite signal intensities have yet to be established. We studied 13 healthy young adults with a multiple-section lH-MRSI technique. The metabolite signals measured were N-acetylaspartate (NA), cho-line-containing compounds (CHO), creatine-phosphocreatine (CRE), and lactate. Ten neuroanatomic regions (nine bilateral) were identified in gray matter, white matter, and basal nuclei. Analysis of the data led to the following conclusions: (1) NA and CHO signals from centrum semiovale (CSO) can be used as a normalizing factor to reduce intersubject variability due to external causes; (2) in normal human brain, there is no left versus right asymmetry in the regions studied; (3) statistically significant patterns of signal distribution of NA, CHO, and CRE can be identified in normal human brain; and (4) CSO-normalized metabolite signal intensities and metabolite ratios complement each other for the detection of significant regional differences.

Original languageEnglish
Pages (from-to)1384-1391
Number of pages8
JournalNeurology
Volume45
Issue number7
Publication statusPublished - 1995

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Protons
Young Adult
Phosphocreatine
Creatine
Magnetic Resonance Imaging
Brain
Basal Ganglia
Lactic Acid
N-acetylaspartate
Young Adults
Gray Matter
White Matter
Proton Magnetic Resonance Spectroscopy

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Tedeschi, G., Bertolino, A., Righini, A., Campbell, G., Raman, R., Duyn, J. H., ... Di Chiro, G. (1995). Brain regional distribution pattern of metabolite signal intensities in young adults by proton magnetic resonance spectroscopic imaging. Neurology, 45(7), 1384-1391.

Brain regional distribution pattern of metabolite signal intensities in young adults by proton magnetic resonance spectroscopic imaging. / Tedeschi, Gioacchino; Bertolino, A.; Righini, A.; Campbell, G.; Raman, R.; Duyn, J. H.; Moonen, C. T W; Alger, J. R.; Di Chiro, G.

In: Neurology, Vol. 45, No. 7, 1995, p. 1384-1391.

Research output: Contribution to journalArticle

Tedeschi, G, Bertolino, A, Righini, A, Campbell, G, Raman, R, Duyn, JH, Moonen, CTW, Alger, JR & Di Chiro, G 1995, 'Brain regional distribution pattern of metabolite signal intensities in young adults by proton magnetic resonance spectroscopic imaging', Neurology, vol. 45, no. 7, pp. 1384-1391.
Tedeschi G, Bertolino A, Righini A, Campbell G, Raman R, Duyn JH et al. Brain regional distribution pattern of metabolite signal intensities in young adults by proton magnetic resonance spectroscopic imaging. Neurology. 1995;45(7):1384-1391.
Tedeschi, Gioacchino ; Bertolino, A. ; Righini, A. ; Campbell, G. ; Raman, R. ; Duyn, J. H. ; Moonen, C. T W ; Alger, J. R. ; Di Chiro, G. / Brain regional distribution pattern of metabolite signal intensities in young adults by proton magnetic resonance spectroscopic imaging. In: Neurology. 1995 ; Vol. 45, No. 7. pp. 1384-1391.
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