Abstract
Proton magnetic resonance spectroscopy (1 H-MRS) is evolving from single-volume localized acquisitions to multiple-volume acquisitions using magnetic resonance spectroscopic imaging (lH-MRSI). The normal regional patterns of 1H-MRSI-detectable metabolite signal intensities have yet to be established. We studied 13 healthy young adults with a multiple-section lH-MRSI technique. The metabolite signals measured were N-acetylaspartate (NA), cho-line-containing compounds (CHO), creatine-phosphocreatine (CRE), and lactate. Ten neuroanatomic regions (nine bilateral) were identified in gray matter, white matter, and basal nuclei. Analysis of the data led to the following conclusions: (1) NA and CHO signals from centrum semiovale (CSO) can be used as a normalizing factor to reduce intersubject variability due to external causes; (2) in normal human brain, there is no left versus right asymmetry in the regions studied; (3) statistically significant patterns of signal distribution of NA, CHO, and CRE can be identified in normal human brain; and (4) CSO-normalized metabolite signal intensities and metabolite ratios complement each other for the detection of significant regional differences.
| Original language | English |
|---|---|
| Pages (from-to) | 1384-1391 |
| Number of pages | 8 |
| Journal | Neurology |
| Volume | 45 |
| Issue number | 7 |
| Publication status | Published - 1995 |
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ASJC Scopus subject areas
- Arts and Humanities (miscellaneous)
- Clinical Neurology
- Neuroscience(all)
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Brain regional distribution pattern of metabolite signal intensities in young adults by proton magnetic resonance spectroscopic imaging. / Tedeschi, Gioacchino; Bertolino, A.; Righini, A.; Campbell, G.; Raman, R.; Duyn, J. H.; Moonen, C. T W; Alger, J. R.; Di Chiro, G.
In: Neurology, Vol. 45, No. 7, 1995, p. 1384-1391.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Brain regional distribution pattern of metabolite signal intensities in young adults by proton magnetic resonance spectroscopic imaging
AU - Tedeschi, Gioacchino
AU - Bertolino, A.
AU - Righini, A.
AU - Campbell, G.
AU - Raman, R.
AU - Duyn, J. H.
AU - Moonen, C. T W
AU - Alger, J. R.
AU - Di Chiro, G.
PY - 1995
Y1 - 1995
N2 - Proton magnetic resonance spectroscopy (1 H-MRS) is evolving from single-volume localized acquisitions to multiple-volume acquisitions using magnetic resonance spectroscopic imaging (lH-MRSI). The normal regional patterns of 1H-MRSI-detectable metabolite signal intensities have yet to be established. We studied 13 healthy young adults with a multiple-section lH-MRSI technique. The metabolite signals measured were N-acetylaspartate (NA), cho-line-containing compounds (CHO), creatine-phosphocreatine (CRE), and lactate. Ten neuroanatomic regions (nine bilateral) were identified in gray matter, white matter, and basal nuclei. Analysis of the data led to the following conclusions: (1) NA and CHO signals from centrum semiovale (CSO) can be used as a normalizing factor to reduce intersubject variability due to external causes; (2) in normal human brain, there is no left versus right asymmetry in the regions studied; (3) statistically significant patterns of signal distribution of NA, CHO, and CRE can be identified in normal human brain; and (4) CSO-normalized metabolite signal intensities and metabolite ratios complement each other for the detection of significant regional differences.
AB - Proton magnetic resonance spectroscopy (1 H-MRS) is evolving from single-volume localized acquisitions to multiple-volume acquisitions using magnetic resonance spectroscopic imaging (lH-MRSI). The normal regional patterns of 1H-MRSI-detectable metabolite signal intensities have yet to be established. We studied 13 healthy young adults with a multiple-section lH-MRSI technique. The metabolite signals measured were N-acetylaspartate (NA), cho-line-containing compounds (CHO), creatine-phosphocreatine (CRE), and lactate. Ten neuroanatomic regions (nine bilateral) were identified in gray matter, white matter, and basal nuclei. Analysis of the data led to the following conclusions: (1) NA and CHO signals from centrum semiovale (CSO) can be used as a normalizing factor to reduce intersubject variability due to external causes; (2) in normal human brain, there is no left versus right asymmetry in the regions studied; (3) statistically significant patterns of signal distribution of NA, CHO, and CRE can be identified in normal human brain; and (4) CSO-normalized metabolite signal intensities and metabolite ratios complement each other for the detection of significant regional differences.
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M3 - Article
C2 - 7617201
AN - SCOPUS:0029082581
VL - 45
SP - 1384
EP - 1391
JO - Neurology
JF - Neurology
SN - 0028-3878
IS - 7
ER -