Brain reserve and cognitive reserve in multiple sclerosis: What you've got and how you use it

James F. Sumowski, Maria A. Rocca, Victoria M. Leavitt, Gianna Riccitelli, Giancarlo Comi, John Deluca, Massimo Filippi

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

Objective: We first tested the brain reserve (BR) hypothesis in multiple sclerosis (MS) by examining whether larger maximal lifetime brain volume (MLBV; determined by genetics) protects against disease-related cognitive impairment, and then investigated whether cognitive reserve (CR) gained through life experience (intellectually enriching leisure activities) protects against cognitive decline independently of MLBV (BR). Methods: Sixty-two patients with MS (41 relapsing-remitting MS, 21 secondary progressive MS) received MRIs to estimate BR (MLBV, estimated with intracranial volume [ICV]) and disease burden (T2 lesion load; atrophy of gray matter, white matter, thalamus, and hippocampus). Early-life cognitive leisure was measured as a source of CR. We assessed cognitive status with tasks of cognitive efficiency and memory. Hierarchical regressions were used to investigate whether higher BR (ICV) protects against cognitive impairment, and whether higher CR (leisure) independently protects against cognitive impairment over and above BR. Results: Cognitive status was positively associated with ICV (R2 = 0.066, p = 0.017). An ICV x disease burden interaction (R2 = 0.050, p = 0.030) revealed that larger ICV attenuated the impact of disease burden on cognition. Controlling for BR, higher education (R2 = 0.047, p = 0.030) and leisure (R2 = 0.090, p = 0.001) predicted better cognition. A leisure x disease burden interaction (R2 = 0.037, p = 0.030) showed that leisure independently attenuated the impact of disease burden on cognition. Follow-up analyses revealed that BR protected against cognitive inefficiency, not memory deficits, whereas CR was more protective against memory deficits than cognitive inefficiency. Conclusion: We provide evidence of BR in MS, and show that CR independently protects against disease-related cognitive decline over and above BR. Lifestyle choices protect against cognitive impairment independently of genetic factors outside of one's control.

Original languageEnglish
Pages (from-to)2186-2193
Number of pages8
JournalNeurology
Volume80
Issue number24
DOIs
Publication statusPublished - Jun 11 2013

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Cognitive Reserve
Multiple Sclerosis
Leisure Activities
Cognition
Memory Disorders
Chronic Progressive Multiple Sclerosis
Relapsing-Remitting Multiple Sclerosis
Life Change Events
Leisure

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)

Cite this

Brain reserve and cognitive reserve in multiple sclerosis : What you've got and how you use it. / Sumowski, James F.; Rocca, Maria A.; Leavitt, Victoria M.; Riccitelli, Gianna; Comi, Giancarlo; Deluca, John; Filippi, Massimo.

In: Neurology, Vol. 80, No. 24, 11.06.2013, p. 2186-2193.

Research output: Contribution to journalArticle

Sumowski, James F. ; Rocca, Maria A. ; Leavitt, Victoria M. ; Riccitelli, Gianna ; Comi, Giancarlo ; Deluca, John ; Filippi, Massimo. / Brain reserve and cognitive reserve in multiple sclerosis : What you've got and how you use it. In: Neurology. 2013 ; Vol. 80, No. 24. pp. 2186-2193.
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