Brain serotonin metabolism in isolated aggressive mice

E. Giacalone, M. Tansella, L. Valzelli, S. Garattini

Research output: Contribution to journalArticlepeer-review


Isolation of Albino-Swiss male mice for various periods of time induces a decrease of adrenal weight and an increase of food intake. The level of brain 5-hydroxy-tryptamine (5HT) was unaffected while a decrease of brain 5-hydroxyindolacetic acid (5HIAA) was evident beginning the first day of isolation. The turnover rate of brain 5HT, measured after blockade of monoaminoxidase in vivo, was decreased in isolated mice. Similar changes were observed also in discrete areas of the brain. There was no temporal correlation between the alteration of brain 5HT metabolism and the onset of an aggressive behavior. However female mice and two strains of rats which do not become aggressive after prolonged isolation did not show any change in brain 5HT turnover rate.

Original languageEnglish
Pages (from-to)1315-1327
Number of pages13
JournalBiochemical Pharmacology
Issue number7
Publication statusPublished - Jul 1968

ASJC Scopus subject areas

  • Pharmacology


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