Brain stem neurons projecting to neocortex: A HRP study in the cat

M. Bentivoglio, G. Macchi, P. Rossini, E. Tempesta

Research output: Contribution to journalArticlepeer-review


The cortical projections of the brain stem were investigated in detail in the cat by means of the horseradish peroxidase (HRP) retrograde axonal transport. Most of the cells providing ascending fibers to the neocortex were located in the pons (locus coeruleus and related structures, central gray substance, dorsal tegmental nucleus, raphe nuclei, reticular nuclei); labeled neurons were also identified in the mesencephalon, mainly in the periaqueductal gray and in the nucleus linearis rostralis. These projections, and particularly the pontine fibers, were diffusely distributed throughout the cerebral cortex. The results are compared with the data previously obtained by the use of anterograde and retrograde tracing techniques.

Original languageEnglish
Pages (from-to)489-498
Number of pages10
JournalExperimental Brain Research
Issue number4
Publication statusPublished - Apr 1978


  • Brain stem
  • Cortical projections
  • Horseradish Peroxidase
  • Locus coeruleus
  • Raphe nuclei

ASJC Scopus subject areas

  • Neuroscience(all)


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