Brain structural changes in spasmodic dysphonia: A multimodal magnetic resonance imaging study

Vladimir S. Kostic, Federica Agosta, Lidia Sarro, Aleksandra Tomić, Nikola Kresojević, Sebastiano Galantucci, Marina Svetel, Paola Valsasina, Massimo Filippi

Research output: Contribution to journalArticle

Abstract

Introduction The pathophysiology of spasmodic dysphonia is poorly understood. This study evaluated patterns of cortical morphology, basal ganglia, and white matter microstructural alterations in patients with spasmodic dysphonia relative to healthy controls. Methods T1-weighted and diffusion tensor magnetic resonance imaging (MRI) scans were obtained from 13 spasmodic dysphonia patients and 30 controls. Tract-based spatial statistics was applied to compare diffusion tensor MRI indices (i.e., mean, radial and axial diffusivities, and fractional anisotropy) between groups on a voxel-by-voxel basis. Cortical measures were analyzed using surface-based morphometry. Basal ganglia were segmented on T1-weighted images, and volumes and diffusion tensor MRI metrics of nuclei were measured. Results Relative to controls, patients with spasmodic dysphonia showed increased cortical surface area of the primary somatosensory cortex bilaterally in a region consistent with the buccal sensory representation, as well as right primary motor cortex, left superior temporal, supramarginal and superior frontal gyri. A decreased cortical area was found in the rolandic operculum bilaterally, left superior/inferior parietal and lingual gyri, as well as in the right angular gyrus. Compared to controls, spasmodic dysphonia patients showed increased diffusivities and decreased fractional anisotropy of the corpus callosum and major white matter tracts, in the right hemisphere. Altered diffusion tensor MRI measures were found in the right caudate and putamen nuclei with no volumetric changes. Conclusions Multi-level alterations in voice-controlling networks, that included regions devoted not only to sensorimotor integration, motor preparation and motor execution, but also processing of auditory and visual information during speech, might have a role in the pathophysiology of spasmodic dysphonia.
Original languageEnglish
Pages (from-to)78 - 84
Number of pages7
JournalParkinsonism and Related Disorders
Volume25
DOIs
Publication statusPublished - Apr 1 2016

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Dysphonia
Diffusion Magnetic Resonance Imaging
Magnetic Resonance Imaging
Brain
Anisotropy
Basal Ganglia
Occipital Lobe
Parietal Lobe
Somatosensory Cortex
Cheek
Corpus Callosum
Caudate Nucleus
Putamen
Motor Cortex
Prefrontal Cortex

Keywords

  • Basal ganglia
  • Cortical morphology
  • MRI
  • Spasmodic dysphonia
  • White matter microstructure

ASJC Scopus subject areas

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology

Cite this

Brain structural changes in spasmodic dysphonia: A multimodal magnetic resonance imaging study. / Kostic, Vladimir S.; Agosta, Federica; Sarro, Lidia; Tomić, Aleksandra; Kresojević, Nikola; Galantucci, Sebastiano; Svetel, Marina; Valsasina, Paola; Filippi, Massimo.

In: Parkinsonism and Related Disorders, Vol. 25, 01.04.2016, p. 78 - 84.

Research output: Contribution to journalArticle

Kostic, Vladimir S. ; Agosta, Federica ; Sarro, Lidia ; Tomić, Aleksandra ; Kresojević, Nikola ; Galantucci, Sebastiano ; Svetel, Marina ; Valsasina, Paola ; Filippi, Massimo. / Brain structural changes in spasmodic dysphonia: A multimodal magnetic resonance imaging study. In: Parkinsonism and Related Disorders. 2016 ; Vol. 25. pp. 78 - 84.
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AU - Agosta, Federica

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AU - Kresojević, Nikola

AU - Galantucci, Sebastiano

AU - Svetel, Marina

AU - Valsasina, Paola

AU - Filippi, Massimo

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AB - Introduction The pathophysiology of spasmodic dysphonia is poorly understood. This study evaluated patterns of cortical morphology, basal ganglia, and white matter microstructural alterations in patients with spasmodic dysphonia relative to healthy controls. Methods T1-weighted and diffusion tensor magnetic resonance imaging (MRI) scans were obtained from 13 spasmodic dysphonia patients and 30 controls. Tract-based spatial statistics was applied to compare diffusion tensor MRI indices (i.e., mean, radial and axial diffusivities, and fractional anisotropy) between groups on a voxel-by-voxel basis. Cortical measures were analyzed using surface-based morphometry. Basal ganglia were segmented on T1-weighted images, and volumes and diffusion tensor MRI metrics of nuclei were measured. Results Relative to controls, patients with spasmodic dysphonia showed increased cortical surface area of the primary somatosensory cortex bilaterally in a region consistent with the buccal sensory representation, as well as right primary motor cortex, left superior temporal, supramarginal and superior frontal gyri. A decreased cortical area was found in the rolandic operculum bilaterally, left superior/inferior parietal and lingual gyri, as well as in the right angular gyrus. Compared to controls, spasmodic dysphonia patients showed increased diffusivities and decreased fractional anisotropy of the corpus callosum and major white matter tracts, in the right hemisphere. Altered diffusion tensor MRI measures were found in the right caudate and putamen nuclei with no volumetric changes. Conclusions Multi-level alterations in voice-controlling networks, that included regions devoted not only to sensorimotor integration, motor preparation and motor execution, but also processing of auditory and visual information during speech, might have a role in the pathophysiology of spasmodic dysphonia.

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