Brain structural damage in spinocerebellar ataxia type 1: A VBM study

A. Ginestroni, R. Della Nave, C. Tessa, M. Giannelli, D. De Grandis, R. Plasmati, F. Salvi, S. Piacentini, M. Mascalchi

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background and objective :Neuropathological description of the brain in spinocerebellar ataxia type 1(SCA1) is limited to a few cases. Voxel-based morphometry (VBM) enables an unbiased in vivo whole-brain quantitative analysis of regional differences in gray matter (GM) and white matter (WM) volume. We assessed with VBM the structural damage in patients with genetically confirmed SCA1. Method :Fifteen SCA1 patients and 15 age-matched healthy controls underwent MR examination with acquisition of high-resolution T1-weighted images. The results were correlated with the disease duration and severity of the clinical deficit assessed with the International Cerebellar Ataxia Rating Scale (ICARS) and Inherited Ataxia Clinical Rating Scale (IACRS). Results :As compared to controls, patients with SCA1 showed a significant (p <0.05 corrected for multiple comparison) symmetric loss of volume of the GM in the rostral cerebellar vermis and paramedian portions of the anterior cerebellar lobes. WM was decreased in the peridentate region and middle cerebellar peduncles but not in the pons. No GM or WM volume loss was found in the cerebral hemispheres. The cerebellar and brainstem GM and WM volume loss correlated with disease duration and the ICARS and IACRS scores. Conclusions :VBM confirms that atrophy predominantly involves the brainstem and cerebellum in SCA1. The correlation with the clinical features indicates that VBM might be useful to monitor disease progression.

Original languageEnglish
Pages (from-to)1153-1158
Number of pages6
JournalJournal of Neurology
Volume255
Issue number8
DOIs
Publication statusPublished - Aug 2008

Fingerprint

Spinocerebellar Ataxias
Brain
Cerebellar Ataxia
Ataxia
Brain Stem
Pons
Cerebrum
Cerebellum
Atrophy
Disease Progression
White Matter
Gray Matter

Keywords

  • Ataxia
  • MR imaging
  • Spinocerebellar ataxia type 1
  • Voxel-based morphometry

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Ginestroni, A., Della Nave, R., Tessa, C., Giannelli, M., De Grandis, D., Plasmati, R., ... Mascalchi, M. (2008). Brain structural damage in spinocerebellar ataxia type 1: A VBM study. Journal of Neurology, 255(8), 1153-1158. https://doi.org/10.1007/s00415-008-0860-4

Brain structural damage in spinocerebellar ataxia type 1 : A VBM study. / Ginestroni, A.; Della Nave, R.; Tessa, C.; Giannelli, M.; De Grandis, D.; Plasmati, R.; Salvi, F.; Piacentini, S.; Mascalchi, M.

In: Journal of Neurology, Vol. 255, No. 8, 08.2008, p. 1153-1158.

Research output: Contribution to journalArticle

Ginestroni, A, Della Nave, R, Tessa, C, Giannelli, M, De Grandis, D, Plasmati, R, Salvi, F, Piacentini, S & Mascalchi, M 2008, 'Brain structural damage in spinocerebellar ataxia type 1: A VBM study', Journal of Neurology, vol. 255, no. 8, pp. 1153-1158. https://doi.org/10.1007/s00415-008-0860-4
Ginestroni A, Della Nave R, Tessa C, Giannelli M, De Grandis D, Plasmati R et al. Brain structural damage in spinocerebellar ataxia type 1: A VBM study. Journal of Neurology. 2008 Aug;255(8):1153-1158. https://doi.org/10.1007/s00415-008-0860-4
Ginestroni, A. ; Della Nave, R. ; Tessa, C. ; Giannelli, M. ; De Grandis, D. ; Plasmati, R. ; Salvi, F. ; Piacentini, S. ; Mascalchi, M. / Brain structural damage in spinocerebellar ataxia type 1 : A VBM study. In: Journal of Neurology. 2008 ; Vol. 255, No. 8. pp. 1153-1158.
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