Brain Structure and Degeneration Staging in Friedreich Ataxia: Magnetic Resonance Imaging Volumetrics from the ENIGMA-Ataxia Working Group

Ian H. Harding, Sidhant Chopra, Filippo Arrigoni, Sylvia Boesch, Arturo Brunetti, Sirio Cocozza, Louise A. Corben, Andreas Deistung, Martin Delatycki, Stefano Diciotti, Imis Dogan, Stefania Evangelisti, Marcondes C. França, Sophia L. Göricke, Nellie Georgiou-Karistianis, Laura L. Gramegna, Pierre Gilles Henry, Carlos R. Hernandez-Castillo, Diane Hutter, Neda JahanshadJames M. Joers, Christophe Lenglet, Raffaele Lodi, David N. Manners, Alberto R.M. Martinez, Andrea Martinuzzi, Chiara Marzi, Mario Mascalchi, Wolfgang Nachbauer, Chiara Pane, Denis Peruzzo, Pramod K. Pisharady, Giuseppe Pontillo, Kathrin Reetz, Thiago J.R. Rezende, Sandro Romanzetti, Francesco Saccà, Christoph Scherfler, Jörg B. Schulz, Ambra Stefani, Claudia Testa, Sophia I. Thomopoulos, Dagmar Timmann, Stefania Tirelli, Caterina Tonon, Marinela Vavla, Gary F. Egan, Paul M. Thompson

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Friedreich ataxia (FRDA) is an inherited neurological disease defined by progressive movement incoordination. We undertook a comprehensive characterization of the spatial profile and progressive evolution of structural brain abnormalities in people with FRDA. Methods: A coordinated international analysis of regional brain volume using magnetic resonance imaging data charted the whole-brain profile, interindividual variability, and temporal staging of structural brain differences in 248 individuals with FRDA and 262 healthy controls. Results: The brainstem, dentate nucleus region, and superior and inferior cerebellar peduncles showed the greatest reductions in volume relative to controls (Cohen d = 1.5–2.6). Cerebellar gray matter alterations were most pronounced in lobules I–VI (d = 0.8), whereas cerebral differences occurred most prominently in precentral gyri (d = 0.6) and corticospinal tracts (d = 1.4). Earlier onset age predicted less volume in the motor cerebellum (rmax = 0.35) and peduncles (rmax = 0.36). Disease duration and severity correlated with volume deficits in the dentate nucleus region, brainstem, and superior/inferior cerebellar peduncles (rmax = −0.49); subgrouping showed these to be robust and early features of FRDA, and strong candidates for further biomarker validation. Cerebral white matter abnormalities, particularly in corticospinal pathways, emerge as intermediate disease features. Cerebellar and cerebral gray matter loss, principally targeting motor and sensory systems, preferentially manifests later in the disease course. Interpretation: FRDA is defined by an evolving spatial profile of neuroanatomical changes beyond primary pathology in the cerebellum and spinal cord, in line with its progressive clinical course. The design, interpretation, and generalization of research studies and clinical trials must consider neuroanatomical staging and associated interindividual variability in brain measures. ANN NEUROL 2021.

Original languageEnglish
Pages (from-to)570-583
Number of pages14
JournalAnnals of Neurology
Volume90
Issue number4
DOIs
Publication statusPublished - 2021

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Fingerprint

Dive into the research topics of 'Brain Structure and Degeneration Staging in Friedreich Ataxia: Magnetic Resonance Imaging Volumetrics from the ENIGMA-Ataxia Working Group'. Together they form a unique fingerprint.

Cite this