Brain structure and joint hypermobility: Relevance to the expression of psychiatric symptoms

Jessica A. Eccles, F. D C Beacher, M. A. Gray, C. L. Jones, L. Minati, N. A. Harrison, H. D. Critchley

Research output: Contribution to journalArticlepeer-review

Abstract

Joint hypermobility is overrepresented among people with anxiety and can be associated with abnormal autonomic reactivity. We tested for associations between regional cerebral grey matter and hypermobility in 72 healthy volunteers using voxel-based morphometry of structural brain scans. Strikingly, bilateral amygdala volume distinguished those with from those without hypermobility. The hypermobility group scored higher for interoceptive sensitivity yet were not significantly more anxious. Our findings specifically link hypermobility to the structural integrity of a brain centre implicated in normal and abnormal emotions and physiological responses. Our observations endorse hypermobility as a multisystem phenotype and suggest potential mechanisms mediating clinical vulnerability to neuropsychiatric symptoms.

Original languageEnglish
Pages (from-to)508-509
Number of pages2
JournalBritish Journal of Psychiatry
Volume200
Issue number6
DOIs
Publication statusPublished - Jun 2012

ASJC Scopus subject areas

  • Psychiatry and Mental health

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