Brain susceptibility to oxidative stress in the perinatal period

Serafina Perrone, Luisa M. Tataranno, Gemma Stazzoni, Luca Ramenghi, Giuseppe Buonocore

Research output: Contribution to journalArticle

Abstract

Oxidative stress (OS) occurs at birth in all newborns as a consequence of the hyperoxic challenge due to the transition from the hypoxic intrauterine environment to extrauterine life. Free radical (FRs) sources such as inflammation, hyperoxia, hypoxia, ischaemia-reperfusion, neutrophil and macrophage activation, glutamate and free iron release, all increases the OS during the perinatal period. Newborns, and particularly preterm infants, have reduced antioxidant defences and are not able to counteract the harmful effects of FRs. Energy metabolism is central to life because cells cannot exist without an adequate supply of ATP. Due to its growth, the mammalian brain can be considered as a steady-state system in which ATP production matches ATP utilisation. The developing brain is particularly sensitive to any disturbances in energy generation, and even a short-term interruption can lead to long-lasting and irreversible damage. Whenever energy failure develops, brain damage can occur. Accumulating evidence indicates that OS is implicated in the pathogenesis of many neurological diseases, such as intraventricular haemorrhage, hypoxic-ischaemic encephalopathy and epilepsy.

Original languageEnglish
Pages (from-to)2291-2295
Number of pages5
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume28
DOIs
Publication statusPublished - Nov 20 2015

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Oxidative Stress
Adenosine Triphosphate
Free Radicals
Brain
Newborn Infant
Brain Hypoxia-Ischemia
Neutrophil Activation
Hyperoxia
Macrophage Activation
Premature Infants
Energy Metabolism
Reperfusion
Glutamic Acid
Epilepsy
Ischemia
Iron
Antioxidants
Parturition
Hemorrhage
Inflammation

Keywords

  • Antioxidants
  • brain injury
  • free radicals
  • oxidative damage

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

Cite this

Brain susceptibility to oxidative stress in the perinatal period. / Perrone, Serafina; Tataranno, Luisa M.; Stazzoni, Gemma; Ramenghi, Luca; Buonocore, Giuseppe.

In: Journal of Maternal-Fetal and Neonatal Medicine, Vol. 28, 20.11.2015, p. 2291-2295.

Research output: Contribution to journalArticle

Perrone, Serafina ; Tataranno, Luisa M. ; Stazzoni, Gemma ; Ramenghi, Luca ; Buonocore, Giuseppe. / Brain susceptibility to oxidative stress in the perinatal period. In: Journal of Maternal-Fetal and Neonatal Medicine. 2015 ; Vol. 28. pp. 2291-2295.
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