Abstract
Oxidative stress (OS) occurs at birth in all newborns as a consequence of the hyperoxic challenge due to the transition from the hypoxic intrauterine environment to extrauterine life. Free radical (FRs) sources such as inflammation, hyperoxia, hypoxia, ischaemia-reperfusion, neutrophil and macrophage activation, glutamate and free iron release, all increases the OS during the perinatal period. Newborns, and particularly preterm infants, have reduced antioxidant defences and are not able to counteract the harmful effects of FRs. Energy metabolism is central to life because cells cannot exist without an adequate supply of ATP. Due to its growth, the mammalian brain can be considered as a steady-state system in which ATP production matches ATP utilisation. The developing brain is particularly sensitive to any disturbances in energy generation, and even a short-term interruption can lead to long-lasting and irreversible damage. Whenever energy failure develops, brain damage can occur. Accumulating evidence indicates that OS is implicated in the pathogenesis of many neurological diseases, such as intraventricular haemorrhage, hypoxic-ischaemic encephalopathy and epilepsy.
| Original language | English |
|---|---|
| Pages (from-to) | 2291-2295 |
| Number of pages | 5 |
| Journal | Journal of Maternal-Fetal and Neonatal Medicine |
| Volume | 28 |
| DOIs | |
| Publication status | Published - Nov 20 2015 |
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Keywords
- Antioxidants
- brain injury
- free radicals
- oxidative damage
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Obstetrics and Gynaecology
Cite this
Brain susceptibility to oxidative stress in the perinatal period. / Perrone, Serafina; Tataranno, Luisa M.; Stazzoni, Gemma; Ramenghi, Luca; Buonocore, Giuseppe.
In: Journal of Maternal-Fetal and Neonatal Medicine, Vol. 28, 20.11.2015, p. 2291-2295.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Brain susceptibility to oxidative stress in the perinatal period
AU - Perrone, Serafina
AU - Tataranno, Luisa M.
AU - Stazzoni, Gemma
AU - Ramenghi, Luca
AU - Buonocore, Giuseppe
PY - 2015/11/20
Y1 - 2015/11/20
N2 - Oxidative stress (OS) occurs at birth in all newborns as a consequence of the hyperoxic challenge due to the transition from the hypoxic intrauterine environment to extrauterine life. Free radical (FRs) sources such as inflammation, hyperoxia, hypoxia, ischaemia-reperfusion, neutrophil and macrophage activation, glutamate and free iron release, all increases the OS during the perinatal period. Newborns, and particularly preterm infants, have reduced antioxidant defences and are not able to counteract the harmful effects of FRs. Energy metabolism is central to life because cells cannot exist without an adequate supply of ATP. Due to its growth, the mammalian brain can be considered as a steady-state system in which ATP production matches ATP utilisation. The developing brain is particularly sensitive to any disturbances in energy generation, and even a short-term interruption can lead to long-lasting and irreversible damage. Whenever energy failure develops, brain damage can occur. Accumulating evidence indicates that OS is implicated in the pathogenesis of many neurological diseases, such as intraventricular haemorrhage, hypoxic-ischaemic encephalopathy and epilepsy.
AB - Oxidative stress (OS) occurs at birth in all newborns as a consequence of the hyperoxic challenge due to the transition from the hypoxic intrauterine environment to extrauterine life. Free radical (FRs) sources such as inflammation, hyperoxia, hypoxia, ischaemia-reperfusion, neutrophil and macrophage activation, glutamate and free iron release, all increases the OS during the perinatal period. Newborns, and particularly preterm infants, have reduced antioxidant defences and are not able to counteract the harmful effects of FRs. Energy metabolism is central to life because cells cannot exist without an adequate supply of ATP. Due to its growth, the mammalian brain can be considered as a steady-state system in which ATP production matches ATP utilisation. The developing brain is particularly sensitive to any disturbances in energy generation, and even a short-term interruption can lead to long-lasting and irreversible damage. Whenever energy failure develops, brain damage can occur. Accumulating evidence indicates that OS is implicated in the pathogenesis of many neurological diseases, such as intraventricular haemorrhage, hypoxic-ischaemic encephalopathy and epilepsy.
KW - Antioxidants
KW - brain injury
KW - free radicals
KW - oxidative damage
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U2 - 10.3109/14767058.2013.796170
DO - 10.3109/14767058.2013.796170
M3 - Article
C2 - 23968388
AN - SCOPUS:84946743447
VL - 28
SP - 2291
EP - 2295
JO - Journal of Maternal-Fetal and Neonatal Medicine
JF - Journal of Maternal-Fetal and Neonatal Medicine
SN - 1476-7058
ER -