Brain tissue loss occurs after suppression of enhancement in patients with multiple sclerosis treated with autologous haematopoietic stem cell transplantation

M. Inglese, G. L. Mancardi, E. Pagani, M. A. Rocca, A. Murialdo, R. Saccardi, G. Comi, M. G. Marrosu, G. La Nasa, E. Cocco, V. Cherchi, A. Lugaresi, P. Di Bartolomeo, D. Farina, C. Ialori, A. Tartaro, L. Massacesi, F. Pagliai, A. Bosi, A. RepiceA. Konze, F. Sardanelli, O. Figari, E. Capello, F. Gualandi, L. Dogliotti, A. Marmont, M. P. Sormani, G. Meucci, F. Papineschi, S. Mosti, A. Abruzzese, M. Filippi

Research output: Contribution to journalArticle

Abstract

To assess whether brain tissue loss occurs after profound and sustained suppression of magnetic resonance imaging (MRI) enhancement, we measured brain volume changes from 10 patients with rapidly evolving secondary progressive multiple sclerosis (MS) treated with autologous haematopoietic stem cell transplantation and followed up for 24 months. An average yearly decrease of brain volume of about 1.9% was observed despite only five enhancing lesions seen on triple dose follow up scans of two patients. This indicates that, in MS, progressive loss of tissue can occur independently of concomitant MRI-visible inflammation.

Original languageEnglish
Pages (from-to)643-644
Number of pages2
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume75
Issue number4
Publication statusPublished - Apr 2004

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychiatry and Mental health

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    Inglese, M., Mancardi, G. L., Pagani, E., Rocca, M. A., Murialdo, A., Saccardi, R., Comi, G., Marrosu, M. G., La Nasa, G., Cocco, E., Cherchi, V., Lugaresi, A., Di Bartolomeo, P., Farina, D., Ialori, C., Tartaro, A., Massacesi, L., Pagliai, F., Bosi, A., ... Filippi, M. (2004). Brain tissue loss occurs after suppression of enhancement in patients with multiple sclerosis treated with autologous haematopoietic stem cell transplantation. Journal of Neurology, Neurosurgery and Psychiatry, 75(4), 643-644.