Brain tissue loss occurs after suppression of enhancement in patients with multiple sclerosis treated with autologous haematopoietic stem cell transplantation

M. Inglese, G. L. Mancardi, E. Pagani, M. A. Rocca, A. Murialdo, R. Saccardi, G. Comi, M. G. Marrosu, G. La Nasa, E. Cocco, V. Cherchi, A. Lugaresi, P. Di Bartolomeo, D. Farina, C. Ialori, A. Tartaro, L. Massacesi, F. Pagliai, A. Bosi, A. Repice & 13 others A. Konze, F. Sardanelli, O. Figari, E. Capello, F. Gualandi, L. Dogliotti, A. Marmont, M. P. Sormani, G. Meucci, F. Papineschi, S. Mosti, A. Abruzzese, M. Filippi

Research output: Contribution to journalArticle

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Abstract

To assess whether brain tissue loss occurs after profound and sustained suppression of magnetic resonance imaging (MRI) enhancement, we measured brain volume changes from 10 patients with rapidly evolving secondary progressive multiple sclerosis (MS) treated with autologous haematopoietic stem cell transplantation and followed up for 24 months. An average yearly decrease of brain volume of about 1.9% was observed despite only five enhancing lesions seen on triple dose follow up scans of two patients. This indicates that, in MS, progressive loss of tissue can occur independently of concomitant MRI-visible inflammation.

Original languageEnglish
Pages (from-to)643-644
Number of pages2
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume75
Issue number4
Publication statusPublished - Apr 2004

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Hematopoietic Stem Cell Transplantation
Multiple Sclerosis
Brain
Magnetic Resonance Imaging
Chronic Progressive Multiple Sclerosis
Inflammation

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychiatry and Mental health

Cite this

Brain tissue loss occurs after suppression of enhancement in patients with multiple sclerosis treated with autologous haematopoietic stem cell transplantation. / Inglese, M.; Mancardi, G. L.; Pagani, E.; Rocca, M. A.; Murialdo, A.; Saccardi, R.; Comi, G.; Marrosu, M. G.; La Nasa, G.; Cocco, E.; Cherchi, V.; Lugaresi, A.; Di Bartolomeo, P.; Farina, D.; Ialori, C.; Tartaro, A.; Massacesi, L.; Pagliai, F.; Bosi, A.; Repice, A.; Konze, A.; Sardanelli, F.; Figari, O.; Capello, E.; Gualandi, F.; Dogliotti, L.; Marmont, A.; Sormani, M. P.; Meucci, G.; Papineschi, F.; Mosti, S.; Abruzzese, A.; Filippi, M.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 75, No. 4, 04.2004, p. 643-644.

Research output: Contribution to journalArticle

Inglese, M, Mancardi, GL, Pagani, E, Rocca, MA, Murialdo, A, Saccardi, R, Comi, G, Marrosu, MG, La Nasa, G, Cocco, E, Cherchi, V, Lugaresi, A, Di Bartolomeo, P, Farina, D, Ialori, C, Tartaro, A, Massacesi, L, Pagliai, F, Bosi, A, Repice, A, Konze, A, Sardanelli, F, Figari, O, Capello, E, Gualandi, F, Dogliotti, L, Marmont, A, Sormani, MP, Meucci, G, Papineschi, F, Mosti, S, Abruzzese, A & Filippi, M 2004, 'Brain tissue loss occurs after suppression of enhancement in patients with multiple sclerosis treated with autologous haematopoietic stem cell transplantation', Journal of Neurology, Neurosurgery and Psychiatry, vol. 75, no. 4, pp. 643-644.
Inglese, M. ; Mancardi, G. L. ; Pagani, E. ; Rocca, M. A. ; Murialdo, A. ; Saccardi, R. ; Comi, G. ; Marrosu, M. G. ; La Nasa, G. ; Cocco, E. ; Cherchi, V. ; Lugaresi, A. ; Di Bartolomeo, P. ; Farina, D. ; Ialori, C. ; Tartaro, A. ; Massacesi, L. ; Pagliai, F. ; Bosi, A. ; Repice, A. ; Konze, A. ; Sardanelli, F. ; Figari, O. ; Capello, E. ; Gualandi, F. ; Dogliotti, L. ; Marmont, A. ; Sormani, M. P. ; Meucci, G. ; Papineschi, F. ; Mosti, S. ; Abruzzese, A. ; Filippi, M. / Brain tissue loss occurs after suppression of enhancement in patients with multiple sclerosis treated with autologous haematopoietic stem cell transplantation. In: Journal of Neurology, Neurosurgery and Psychiatry. 2004 ; Vol. 75, No. 4. pp. 643-644.
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AU - Inglese, M.

AU - Mancardi, G. L.

AU - Pagani, E.

AU - Rocca, M. A.

AU - Murialdo, A.

AU - Saccardi, R.

AU - Comi, G.

AU - Marrosu, M. G.

AU - La Nasa, G.

AU - Cocco, E.

AU - Cherchi, V.

AU - Lugaresi, A.

AU - Di Bartolomeo, P.

AU - Farina, D.

AU - Ialori, C.

AU - Tartaro, A.

AU - Massacesi, L.

AU - Pagliai, F.

AU - Bosi, A.

AU - Repice, A.

AU - Konze, A.

AU - Sardanelli, F.

AU - Figari, O.

AU - Capello, E.

AU - Gualandi, F.

AU - Dogliotti, L.

AU - Marmont, A.

AU - Sormani, M. P.

AU - Meucci, G.

AU - Papineschi, F.

AU - Mosti, S.

AU - Abruzzese, A.

AU - Filippi, M.

PY - 2004/4

Y1 - 2004/4

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