Brain tissues atrophy is not always the best structural biomarker of physiological aging: A multimodal cross-sectional study

Andrea Cherubini, Maria Eugenia Caligiuri, Patrice Peran, Umberto Sabatini, Carlo Cosentino, Francesco Amato

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This study presents a voxel-based multiple regression analysis of different magnetic resonance image modalities, including anatomical T1-weighted, T2∗ relaxometry, and diffusion tensor imaging. Quantitative parameters sensitive to complementary brain tissue alterations, including morphometric atrophy, mineralization, microstructural damage, and anisotropy loss, were compared in a linear physiological aging model in 140 healthy subjects (range 20-74 years). The performance of different predictors and the identification of the best biomarker of age-induced structural variation were compared without a priori anatomical knowledge. The best quantitative predictors in several brain regions were iron deposition and microstructural damage, rather than macroscopic tissue atrophy. Age variations were best resolved with a combination of markers, suggesting that multiple predictors better capture age-induced tissue alterations. These findings highlight the importance of a combined evaluation of multimodal biomarkers for the study of aging and point to a number of novel applications for the method described.

Original languageEnglish
Title of host publicationProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages5436-5440
Number of pages5
Volume2015-November
ISBN (Print)9781424492718
DOIs
Publication statusPublished - Nov 4 2015
Event37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015 - Milan, Italy
Duration: Aug 25 2015Aug 29 2015

Other

Other37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015
CountryItaly
CityMilan
Period8/25/158/29/15

Fingerprint

Biomarkers
Atrophy
Brain
Cross-Sectional Studies
Aging of materials
Tissue
Diffusion tensor imaging
Diffusion Tensor Imaging
Anisotropy
Magnetic resonance
Regression analysis
Healthy Volunteers
Magnetic Resonance Spectroscopy
Iron
Regression Analysis

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

Cite this

Cherubini, A., Caligiuri, M. E., Peran, P., Sabatini, U., Cosentino, C., & Amato, F. (2015). Brain tissues atrophy is not always the best structural biomarker of physiological aging: A multimodal cross-sectional study. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS (Vol. 2015-November, pp. 5436-5440). [7319621] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2015.7319621

Brain tissues atrophy is not always the best structural biomarker of physiological aging : A multimodal cross-sectional study. / Cherubini, Andrea; Caligiuri, Maria Eugenia; Peran, Patrice; Sabatini, Umberto; Cosentino, Carlo; Amato, Francesco.

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. Vol. 2015-November Institute of Electrical and Electronics Engineers Inc., 2015. p. 5436-5440 7319621.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Cherubini, A, Caligiuri, ME, Peran, P, Sabatini, U, Cosentino, C & Amato, F 2015, Brain tissues atrophy is not always the best structural biomarker of physiological aging: A multimodal cross-sectional study. in Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. vol. 2015-November, 7319621, Institute of Electrical and Electronics Engineers Inc., pp. 5436-5440, 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015, Milan, Italy, 8/25/15. https://doi.org/10.1109/EMBC.2015.7319621
Cherubini A, Caligiuri ME, Peran P, Sabatini U, Cosentino C, Amato F. Brain tissues atrophy is not always the best structural biomarker of physiological aging: A multimodal cross-sectional study. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. Vol. 2015-November. Institute of Electrical and Electronics Engineers Inc. 2015. p. 5436-5440. 7319621 https://doi.org/10.1109/EMBC.2015.7319621
Cherubini, Andrea ; Caligiuri, Maria Eugenia ; Peran, Patrice ; Sabatini, Umberto ; Cosentino, Carlo ; Amato, Francesco. / Brain tissues atrophy is not always the best structural biomarker of physiological aging : A multimodal cross-sectional study. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. Vol. 2015-November Institute of Electrical and Electronics Engineers Inc., 2015. pp. 5436-5440
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