Abstract
The case of an HIV-infected man from Eritrea previously diagnosed with tuberculosis, who presented neurological impairment and cerebral lesion after having voluntarily stopped anti-tubercular and antiretroviral therapies, is here reported. Treatments associated with steroids and mannitol were administered. The patient’s condition improved, but neuroimaging showed a continuous worsening of the lesion, while a great immunological reconstitution was observed. Brain microsurgery was performed. A tuberculosis diagnosis was supported by pathological and microbiological examinations. Tuberculosis arising during immune reconstitution inflammatory syndrome is a complication of antiretroviral treatment and is considered to be an emerging disorder, especially in countries highly endemic for tuberculosis.
| Original language | English |
|---|---|
| Pages (from-to) | 536-540 |
| Number of pages | 5 |
| Journal | Journal of Infection in Developing Countries |
| Volume | 9 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2015 |
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Keywords
- Antiretroviral therapy
- Central nervous system
- HIV
- Immune reconstitution inflammatory syndrome (IRIS)
- Tuberculoma
- Tuberculosis
ASJC Scopus subject areas
- Infectious Diseases
- Microbiology
- Parasitology
- Virology
Cite this
Brain tuberculosis-associated immune reconstitution inflammatory syndrome in an HIV-positive patient : A biopsy-proven case. / Giancola, Maria Letizia; Baldini, Francesco; Carapella, Carmine Maria; Rizzi, Elisa Busi; Maddaluno, Rita; Alba, Lucia; Antinori, Andrea.
In: Journal of Infection in Developing Countries, Vol. 9, No. 5, 2015, p. 536-540.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Brain tuberculosis-associated immune reconstitution inflammatory syndrome in an HIV-positive patient
T2 - A biopsy-proven case
AU - Giancola, Maria Letizia
AU - Baldini, Francesco
AU - Carapella, Carmine Maria
AU - Rizzi, Elisa Busi
AU - Maddaluno, Rita
AU - Alba, Lucia
AU - Antinori, Andrea
PY - 2015
Y1 - 2015
N2 - The case of an HIV-infected man from Eritrea previously diagnosed with tuberculosis, who presented neurological impairment and cerebral lesion after having voluntarily stopped anti-tubercular and antiretroviral therapies, is here reported. Treatments associated with steroids and mannitol were administered. The patient’s condition improved, but neuroimaging showed a continuous worsening of the lesion, while a great immunological reconstitution was observed. Brain microsurgery was performed. A tuberculosis diagnosis was supported by pathological and microbiological examinations. Tuberculosis arising during immune reconstitution inflammatory syndrome is a complication of antiretroviral treatment and is considered to be an emerging disorder, especially in countries highly endemic for tuberculosis.
AB - The case of an HIV-infected man from Eritrea previously diagnosed with tuberculosis, who presented neurological impairment and cerebral lesion after having voluntarily stopped anti-tubercular and antiretroviral therapies, is here reported. Treatments associated with steroids and mannitol were administered. The patient’s condition improved, but neuroimaging showed a continuous worsening of the lesion, while a great immunological reconstitution was observed. Brain microsurgery was performed. A tuberculosis diagnosis was supported by pathological and microbiological examinations. Tuberculosis arising during immune reconstitution inflammatory syndrome is a complication of antiretroviral treatment and is considered to be an emerging disorder, especially in countries highly endemic for tuberculosis.
KW - Antiretroviral therapy
KW - Central nervous system
KW - HIV
KW - Immune reconstitution inflammatory syndrome (IRIS)
KW - Tuberculoma
KW - Tuberculosis
UR - http://www.scopus.com/inward/record.url?scp=84929572961&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84929572961&partnerID=8YFLogxK
U2 - 10.3855/jidc.5552
DO - 10.3855/jidc.5552
M3 - Article
C2 - 25989176
AN - SCOPUS:84929572961
VL - 9
SP - 536
EP - 540
JO - Journal of Infection in Developing Countries
JF - Journal of Infection in Developing Countries
SN - 1972-2680
IS - 5
ER -