TY - JOUR
T1 - Brain tuberculosis-associated immune reconstitution inflammatory syndrome in an HIV-positive patient
T2 - A biopsy-proven case
AU - Giancola, Maria Letizia
AU - Baldini, Francesco
AU - Carapella, Carmine Maria
AU - Rizzi, Elisa Busi
AU - Maddaluno, Rita
AU - Alba, Lucia
AU - Antinori, Andrea
PY - 2015
Y1 - 2015
N2 - The case of an HIV-infected man from Eritrea previously diagnosed with tuberculosis, who presented neurological impairment and cerebral lesion after having voluntarily stopped anti-tubercular and antiretroviral therapies, is here reported. Treatments associated with steroids and mannitol were administered. The patient’s condition improved, but neuroimaging showed a continuous worsening of the lesion, while a great immunological reconstitution was observed. Brain microsurgery was performed. A tuberculosis diagnosis was supported by pathological and microbiological examinations. Tuberculosis arising during immune reconstitution inflammatory syndrome is a complication of antiretroviral treatment and is considered to be an emerging disorder, especially in countries highly endemic for tuberculosis.
AB - The case of an HIV-infected man from Eritrea previously diagnosed with tuberculosis, who presented neurological impairment and cerebral lesion after having voluntarily stopped anti-tubercular and antiretroviral therapies, is here reported. Treatments associated with steroids and mannitol were administered. The patient’s condition improved, but neuroimaging showed a continuous worsening of the lesion, while a great immunological reconstitution was observed. Brain microsurgery was performed. A tuberculosis diagnosis was supported by pathological and microbiological examinations. Tuberculosis arising during immune reconstitution inflammatory syndrome is a complication of antiretroviral treatment and is considered to be an emerging disorder, especially in countries highly endemic for tuberculosis.
KW - Antiretroviral therapy
KW - Central nervous system
KW - HIV
KW - Immune reconstitution inflammatory syndrome (IRIS)
KW - Tuberculoma
KW - Tuberculosis
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U2 - 10.3855/jidc.5552
DO - 10.3855/jidc.5552
M3 - Article
C2 - 25989176
AN - SCOPUS:84929572961
VL - 9
SP - 536
EP - 540
JO - Journal of Infection in Developing Countries
JF - Journal of Infection in Developing Countries
SN - 1972-2680
IS - 5
ER -