Brain tuberculosis-associated immune reconstitution inflammatory syndrome in an HIV-positive patient: A biopsy-proven case

Research output: Contribution to journalArticle

Abstract

The case of an HIV-infected man from Eritrea previously diagnosed with tuberculosis, who presented neurological impairment and cerebral lesion after having voluntarily stopped anti-tubercular and antiretroviral therapies, is here reported. Treatments associated with steroids and mannitol were administered. The patient’s condition improved, but neuroimaging showed a continuous worsening of the lesion, while a great immunological reconstitution was observed. Brain microsurgery was performed. A tuberculosis diagnosis was supported by pathological and microbiological examinations. Tuberculosis arising during immune reconstitution inflammatory syndrome is a complication of antiretroviral treatment and is considered to be an emerging disorder, especially in countries highly endemic for tuberculosis.

Original languageEnglish
Pages (from-to)536-540
Number of pages5
JournalJournal of Infection in Developing Countries
Volume9
Issue number5
DOIs
Publication statusPublished - 2015

Fingerprint

Immune Reconstitution Inflammatory Syndrome
Tuberculosis
HIV
Biopsy
Brain
Eritrea
Microsurgery
Mannitol
Neuroimaging
Therapeutics
Steroids

Keywords

  • Antiretroviral therapy
  • Central nervous system
  • HIV
  • Immune reconstitution inflammatory syndrome (IRIS)
  • Tuberculoma
  • Tuberculosis

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology
  • Parasitology
  • Virology

Cite this

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abstract = "The case of an HIV-infected man from Eritrea previously diagnosed with tuberculosis, who presented neurological impairment and cerebral lesion after having voluntarily stopped anti-tubercular and antiretroviral therapies, is here reported. Treatments associated with steroids and mannitol were administered. The patient’s condition improved, but neuroimaging showed a continuous worsening of the lesion, while a great immunological reconstitution was observed. Brain microsurgery was performed. A tuberculosis diagnosis was supported by pathological and microbiological examinations. Tuberculosis arising during immune reconstitution inflammatory syndrome is a complication of antiretroviral treatment and is considered to be an emerging disorder, especially in countries highly endemic for tuberculosis.",
keywords = "Antiretroviral therapy, Central nervous system, HIV, Immune reconstitution inflammatory syndrome (IRIS), Tuberculoma, Tuberculosis",
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AU - Giancola, Maria Letizia

AU - Baldini, Francesco

AU - Carapella, Carmine Maria

AU - Rizzi, Elisa Busi

AU - Maddaluno, Rita

AU - Alba, Lucia

AU - Antinori, Andrea

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