Brain tumour stem cells

Angelo L. Vescovi, Rossella Galli, Brent A. Reynolds

Research output: Contribution to journalArticle

Abstract

The dogma that the genesis of new cells is a negligible event in the adult mammalian brain has long influenced our perception and understanding of the origin and development of CNS tumours. The discovery that new neurons and glia are produced throughout life from neural stem cells provides new possibilities for the candidate cells of origin of CNS neoplasias. The emerging hypothesis is that alterations in the cellular and genetic mechanisms that control adult neurogenesis might contribute to brain tumorigenesis, thereby allowing the identification of new therapeutic strategies.

Original languageEnglish
Pages (from-to)425-436
Number of pages12
JournalNature Reviews Cancer
Volume6
Issue number6
DOIs
Publication statusPublished - Jun 2006

ASJC Scopus subject areas

  • Cancer Research

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