Brain tumour stem cells

Angelo L. Vescovi, Rossella Galli, Brent A. Reynolds

Research output: Contribution to journalArticle

718 Citations (Scopus)

Abstract

The dogma that the genesis of new cells is a negligible event in the adult mammalian brain has long influenced our perception and understanding of the origin and development of CNS tumours. The discovery that new neurons and glia are produced throughout life from neural stem cells provides new possibilities for the candidate cells of origin of CNS neoplasias. The emerging hypothesis is that alterations in the cellular and genetic mechanisms that control adult neurogenesis might contribute to brain tumorigenesis, thereby allowing the identification of new therapeutic strategies.

Original languageEnglish
Pages (from-to)425-436
Number of pages12
JournalNature Reviews Cancer
Volume6
Issue number6
DOIs
Publication statusPublished - Jun 2006

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Neoplastic Stem Cells
Brain Neoplasms
Neural Stem Cells
Neurogenesis
Brain
Neuroglia
Neoplasms
Carcinogenesis
Neurons
Therapeutics

ASJC Scopus subject areas

  • Cancer Research

Cite this

Brain tumour stem cells. / Vescovi, Angelo L.; Galli, Rossella; Reynolds, Brent A.

In: Nature Reviews Cancer, Vol. 6, No. 6, 06.2006, p. 425-436.

Research output: Contribution to journalArticle

Vescovi, Angelo L. ; Galli, Rossella ; Reynolds, Brent A. / Brain tumour stem cells. In: Nature Reviews Cancer. 2006 ; Vol. 6, No. 6. pp. 425-436.
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