Brain white matter lesions in an Italian family with Charcot-Marie-Tooth disease

Simona Sacco, Rocco Totaro, Stefano Bastianello, Carmine Marini, Antonio Carolei

Research output: Contribution to journalArticlepeer-review

Abstract

Type 1A, the most common form of Charcot-Marie-Tooth (CMT1A) disease, is characterized by demyelination of the peripheral nervous system. So far, only a few cases of the disease with concomitant brain white matter lesions have been described. We report an Italian family with CMT1A disease, consisting of the proband and 4 affected members, presenting with concomitant brain white matter lesions at magnetic resonance imaging. The association is particularly fascinating and might depend on an autoimmune mechanism, not yet clarified.

Original languageEnglish
Pages (from-to)168-171
Number of pages4
JournalEuropean Neurology
Volume51
Issue number3
DOIs
Publication statusPublished - 2004

Keywords

  • Charcot-Marie-Tooth disease
  • Immune system
  • White matter lesions

ASJC Scopus subject areas

  • Clinical Neurology

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