Brain white matter organisation in adolescence is related to childhood cerebral responses to facial expressions and harm avoidance

Matilde Taddei, Marco Tettamanti, Annalisa Zanoni, Stefano Cappa, Marco Battaglia

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

While white matter structural integrity is likely to influence the responses to social-emotional stimuli and emotional regulation during development, no longitudinal data are available on such relationships.We investigated the relationships between white matter Fractional Anisotropy (FA) derived by DTI voxelwise Tract Based Spatial Statistics (TBSS) and tractography measured at ages 14-15, and cerebral event-related N400 amplitudes in response to happy, neutral and angry facial expressions and Cloninger's Harm Avoidance (HA) measured at ages 7-9.Whole-skeleton TBSS analyses revealed reduced FA associated to smaller N400 amplitudes in response to anger, and to higher HA. Region-of-Interest TBSS analyses showed high correlations (ranging - 0.69-0.82, p <0.01-0.001) between FA and N400 amplitudes across the Inferior Longitudinal, the Inferior Frontoccipital, and the left Uncinate Fasciculus, and between FA and Harm Avoidance in right Uncinate Fasciculus (- 0.71, p <0.01). Tractography showed that these relationships were mainly present in the left Inferior Longitudinal and the right Inferior Fronto-Occipital Fasciculus for N400 amplitudes, and in the right Uncinate Fasciculus for HA.Ventral limbic pathways' white matter organisation affects the neural responses to expressions - such as anger - that are perceptually more challenging and/or communicate social rejection, and compounds the neural pathways that predispose to avoidant behaviour and shyness with strangers.

Original languageEnglish
Pages (from-to)1394-1401
Number of pages8
JournalNeuroImage
Volume61
Issue number4
DOIs
Publication statusPublished - Jul 16 2012

Fingerprint

Facial Expression
Anisotropy
Spatial Analysis
Anger
Brain
Shyness
Social Distance
Neural Pathways
Skeleton
White Matter

Keywords

  • Development
  • Event related potentials
  • Facial expressions
  • Fractional anisotropy
  • Harm avoidance
  • Social anxiety

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

Cite this

Brain white matter organisation in adolescence is related to childhood cerebral responses to facial expressions and harm avoidance. / Taddei, Matilde; Tettamanti, Marco; Zanoni, Annalisa; Cappa, Stefano; Battaglia, Marco.

In: NeuroImage, Vol. 61, No. 4, 16.07.2012, p. 1394-1401.

Research output: Contribution to journalArticle

Taddei, Matilde ; Tettamanti, Marco ; Zanoni, Annalisa ; Cappa, Stefano ; Battaglia, Marco. / Brain white matter organisation in adolescence is related to childhood cerebral responses to facial expressions and harm avoidance. In: NeuroImage. 2012 ; Vol. 61, No. 4. pp. 1394-1401.
@article{27e07e91f74b4a3eb6c6b16f49b2b6d0,
title = "Brain white matter organisation in adolescence is related to childhood cerebral responses to facial expressions and harm avoidance",
abstract = "While white matter structural integrity is likely to influence the responses to social-emotional stimuli and emotional regulation during development, no longitudinal data are available on such relationships.We investigated the relationships between white matter Fractional Anisotropy (FA) derived by DTI voxelwise Tract Based Spatial Statistics (TBSS) and tractography measured at ages 14-15, and cerebral event-related N400 amplitudes in response to happy, neutral and angry facial expressions and Cloninger's Harm Avoidance (HA) measured at ages 7-9.Whole-skeleton TBSS analyses revealed reduced FA associated to smaller N400 amplitudes in response to anger, and to higher HA. Region-of-Interest TBSS analyses showed high correlations (ranging - 0.69-0.82, p <0.01-0.001) between FA and N400 amplitudes across the Inferior Longitudinal, the Inferior Frontoccipital, and the left Uncinate Fasciculus, and between FA and Harm Avoidance in right Uncinate Fasciculus (- 0.71, p <0.01). Tractography showed that these relationships were mainly present in the left Inferior Longitudinal and the right Inferior Fronto-Occipital Fasciculus for N400 amplitudes, and in the right Uncinate Fasciculus for HA.Ventral limbic pathways' white matter organisation affects the neural responses to expressions - such as anger - that are perceptually more challenging and/or communicate social rejection, and compounds the neural pathways that predispose to avoidant behaviour and shyness with strangers.",
keywords = "Development, Event related potentials, Facial expressions, Fractional anisotropy, Harm avoidance, Social anxiety",
author = "Matilde Taddei and Marco Tettamanti and Annalisa Zanoni and Stefano Cappa and Marco Battaglia",
year = "2012",
month = "7",
day = "16",
doi = "10.1016/j.neuroimage.2012.03.062",
language = "English",
volume = "61",
pages = "1394--1401",
journal = "NeuroImage",
issn = "1053-8119",
publisher = "Academic Press Inc.",
number = "4",

}

TY - JOUR

T1 - Brain white matter organisation in adolescence is related to childhood cerebral responses to facial expressions and harm avoidance

AU - Taddei, Matilde

AU - Tettamanti, Marco

AU - Zanoni, Annalisa

AU - Cappa, Stefano

AU - Battaglia, Marco

PY - 2012/7/16

Y1 - 2012/7/16

N2 - While white matter structural integrity is likely to influence the responses to social-emotional stimuli and emotional regulation during development, no longitudinal data are available on such relationships.We investigated the relationships between white matter Fractional Anisotropy (FA) derived by DTI voxelwise Tract Based Spatial Statistics (TBSS) and tractography measured at ages 14-15, and cerebral event-related N400 amplitudes in response to happy, neutral and angry facial expressions and Cloninger's Harm Avoidance (HA) measured at ages 7-9.Whole-skeleton TBSS analyses revealed reduced FA associated to smaller N400 amplitudes in response to anger, and to higher HA. Region-of-Interest TBSS analyses showed high correlations (ranging - 0.69-0.82, p <0.01-0.001) between FA and N400 amplitudes across the Inferior Longitudinal, the Inferior Frontoccipital, and the left Uncinate Fasciculus, and between FA and Harm Avoidance in right Uncinate Fasciculus (- 0.71, p <0.01). Tractography showed that these relationships were mainly present in the left Inferior Longitudinal and the right Inferior Fronto-Occipital Fasciculus for N400 amplitudes, and in the right Uncinate Fasciculus for HA.Ventral limbic pathways' white matter organisation affects the neural responses to expressions - such as anger - that are perceptually more challenging and/or communicate social rejection, and compounds the neural pathways that predispose to avoidant behaviour and shyness with strangers.

AB - While white matter structural integrity is likely to influence the responses to social-emotional stimuli and emotional regulation during development, no longitudinal data are available on such relationships.We investigated the relationships between white matter Fractional Anisotropy (FA) derived by DTI voxelwise Tract Based Spatial Statistics (TBSS) and tractography measured at ages 14-15, and cerebral event-related N400 amplitudes in response to happy, neutral and angry facial expressions and Cloninger's Harm Avoidance (HA) measured at ages 7-9.Whole-skeleton TBSS analyses revealed reduced FA associated to smaller N400 amplitudes in response to anger, and to higher HA. Region-of-Interest TBSS analyses showed high correlations (ranging - 0.69-0.82, p <0.01-0.001) between FA and N400 amplitudes across the Inferior Longitudinal, the Inferior Frontoccipital, and the left Uncinate Fasciculus, and between FA and Harm Avoidance in right Uncinate Fasciculus (- 0.71, p <0.01). Tractography showed that these relationships were mainly present in the left Inferior Longitudinal and the right Inferior Fronto-Occipital Fasciculus for N400 amplitudes, and in the right Uncinate Fasciculus for HA.Ventral limbic pathways' white matter organisation affects the neural responses to expressions - such as anger - that are perceptually more challenging and/or communicate social rejection, and compounds the neural pathways that predispose to avoidant behaviour and shyness with strangers.

KW - Development

KW - Event related potentials

KW - Facial expressions

KW - Fractional anisotropy

KW - Harm avoidance

KW - Social anxiety

UR - http://www.scopus.com/inward/record.url?scp=84861470922&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84861470922&partnerID=8YFLogxK

U2 - 10.1016/j.neuroimage.2012.03.062

DO - 10.1016/j.neuroimage.2012.03.062

M3 - Article

VL - 61

SP - 1394

EP - 1401

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

IS - 4

ER -