Brainstem involvement in Unverricht-Lundborg disease (EPM1): An MRI and 1H MRS study

M. Mascalchi; R. Michelucci; M. Cosottini; C. Tessa; F. Lolli; P. Riguzzi; A. E. Lehesjoki; M. Tosetti; N. Villari; C. A. Tassinari

Brainstem involvement in Unverricht-Lundborg disease (EPM1): An MRI and 1H MRS study

M. Mascalchi, R. Michelucci, M. Cosottini, C. Tessa, F. Lolli, P. Riguzzi, A. E. Lehesjoki, M. Tosetti, N. Villari, C. A. Tassinari

Research output: Contribution to journal › Article › peer-review

Abstract

MRI of the brain and proton MRS (¹H MRS) of the pons and dentate were obtained in 10 patients with genetically confirmed Unverricht-Lundborg disease (EPM1) and 20 control subjects. Patients with EPM1 showed (p ≤ 0.01) loss of bulk of the basis pontis, medulla, and cerebellar hemispheres. Cerebral atrophy was present in six patients. The N-acetylaspartate/creatine and choline/creatine ratios were reduced in the pons but not in the dentate (p ≤ 0.005). Brainstem involvement could play a role in pathophysiology of EPM1.

Original language	English
Pages (from-to)	1686-1689
Number of pages	4
Journal	Neurology
Volume	58
Issue number	11
Publication status	Published - Jun 11 2002

ASJC Scopus subject areas

Neuroscience(all)

Cite this

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title = "Brainstem involvement in Unverricht-Lundborg disease (EPM1): An MRI and 1H MRS study",

abstract = "MRI of the brain and proton MRS (1H MRS) of the pons and dentate were obtained in 10 patients with genetically confirmed Unverricht-Lundborg disease (EPM1) and 20 control subjects. Patients with EPM1 showed (p ≤ 0.01) loss of bulk of the basis pontis, medulla, and cerebellar hemispheres. Cerebral atrophy was present in six patients. The N-acetylaspartate/creatine and choline/creatine ratios were reduced in the pons but not in the dentate (p ≤ 0.005). Brainstem involvement could play a role in pathophysiology of EPM1.",

author = "M. Mascalchi and R. Michelucci and M. Cosottini and C. Tessa and F. Lolli and P. Riguzzi and Lehesjoki, {A. E.} and M. Tosetti and N. Villari and Tassinari, {C. A.}",

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T2 - An MRI and 1H MRS study

AU - Mascalchi, M.

AU - Michelucci, R.

AU - Cosottini, M.

AU - Tessa, C.

AU - Lolli, F.

AU - Riguzzi, P.

AU - Lehesjoki, A. E.

AU - Tosetti, M.

AU - Villari, N.

AU - Tassinari, C. A.

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N2 - MRI of the brain and proton MRS (1H MRS) of the pons and dentate were obtained in 10 patients with genetically confirmed Unverricht-Lundborg disease (EPM1) and 20 control subjects. Patients with EPM1 showed (p ≤ 0.01) loss of bulk of the basis pontis, medulla, and cerebellar hemispheres. Cerebral atrophy was present in six patients. The N-acetylaspartate/creatine and choline/creatine ratios were reduced in the pons but not in the dentate (p ≤ 0.005). Brainstem involvement could play a role in pathophysiology of EPM1.

AB - MRI of the brain and proton MRS (1H MRS) of the pons and dentate were obtained in 10 patients with genetically confirmed Unverricht-Lundborg disease (EPM1) and 20 control subjects. Patients with EPM1 showed (p ≤ 0.01) loss of bulk of the basis pontis, medulla, and cerebellar hemispheres. Cerebral atrophy was present in six patients. The N-acetylaspartate/creatine and choline/creatine ratios were reduced in the pons but not in the dentate (p ≤ 0.005). Brainstem involvement could play a role in pathophysiology of EPM1.

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Brainstem involvement in Unverricht-Lundborg disease (EPM1): An MRI and 1H MRS study

Abstract

ASJC Scopus subject areas

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