Brainstem involvement in Unverricht-Lundborg disease (EPM1): An MRI and 1H MRS study

M. Mascalchi, R. Michelucci, M. Cosottini, C. Tessa, F. Lolli, P. Riguzzi, A. E. Lehesjoki, M. Tosetti, N. Villari, C. A. Tassinari

Research output: Contribution to journalArticlepeer-review


MRI of the brain and proton MRS (1H MRS) of the pons and dentate were obtained in 10 patients with genetically confirmed Unverricht-Lundborg disease (EPM1) and 20 control subjects. Patients with EPM1 showed (p ≤ 0.01) loss of bulk of the basis pontis, medulla, and cerebellar hemispheres. Cerebral atrophy was present in six patients. The N-acetylaspartate/creatine and choline/creatine ratios were reduced in the pons but not in the dentate (p ≤ 0.005). Brainstem involvement could play a role in pathophysiology of EPM1.

Original languageEnglish
Pages (from-to)1686-1689
Number of pages4
Issue number11
Publication statusPublished - Jun 11 2002

ASJC Scopus subject areas

  • Neuroscience(all)


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