Abstract
Aquilani R, Boselli M, Boschi F, Viglio S, Iadarola P, Dossena M, Pastoris O, Verri M. Branched-chain amino acids may improve recovery from a vegetative or minimally conscious state in patients with traumatic brain injury: a pilot study. Objective: To investigate whether supplementation with branched-chain amino acids (BCAAs) may improve recovery of patients with a posttraumatic vegetative or minimally conscious state. Design: Patients were randomly assigned to 15 days of intravenous BCAA supplementation (n=22; 19.6g/d) or an isonitrogenous placebo (n=19). Setting: Tertiary care rehabilitation setting. Participants: Patients (N=41; 29 men, 12 women; mean age, 49.5±21y) with a posttraumatic vegetative or minimally conscious state, 47±24 days after the index traumatic event. Intervention: Supplementation with BCAAs. Main Outcome Measure: Disability Rating Scale (DRS) as log10DRS. Results: Fifteen days after admission to the rehabilitation department, the log10DRS score improved significantly only in patients who had received BCAAs (log10DRS score, 1.365±0.08 to 1.294±0.05; P10DRS score in the placebo recipients remained virtually unchanged (log10DRS score, 1.373±0.03 to 1.37±0.03; P not significant). The difference in improvement of log10DRS score between the 2 groups was highly significant (P10DRS point score of .477 or higher (3 as geometric mean) that allowed them to exit the vegetative or minimally conscious state. Conclusions: Supplemented BCAAs may improve the recovery from a vegetative or minimally conscious state in patients with posttraumatic vegetative or minimally conscious state.
| Original language | English |
|---|---|
| Pages (from-to) | 1642-1647 |
| Number of pages | 6 |
| Journal | Archives of Physical Medicine and Rehabilitation |
| Volume | 89 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Sep 2008 |
Fingerprint
Keywords
- Amino acids, branched-chain
- Minimally conscious state
- Rehabilitation
ASJC Scopus subject areas
- Rehabilitation
Cite this
Branched-Chain Amino Acids May Improve Recovery From a Vegetative or Minimally Conscious State in Patients With Traumatic Brain Injury : A Pilot Study. / Aquilani, Roberto; Boselli, Mirella; Boschi, Federica; Viglio, Simona; Iadarola, Paolo; Dossena, Maurizia; Pastoris, Ornella; Verri, Manuela.
In: Archives of Physical Medicine and Rehabilitation, Vol. 89, No. 9, 09.2008, p. 1642-1647.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Branched-Chain Amino Acids May Improve Recovery From a Vegetative or Minimally Conscious State in Patients With Traumatic Brain Injury
T2 - A Pilot Study
AU - Aquilani, Roberto
AU - Boselli, Mirella
AU - Boschi, Federica
AU - Viglio, Simona
AU - Iadarola, Paolo
AU - Dossena, Maurizia
AU - Pastoris, Ornella
AU - Verri, Manuela
PY - 2008/9
Y1 - 2008/9
N2 - Aquilani R, Boselli M, Boschi F, Viglio S, Iadarola P, Dossena M, Pastoris O, Verri M. Branched-chain amino acids may improve recovery from a vegetative or minimally conscious state in patients with traumatic brain injury: a pilot study. Objective: To investigate whether supplementation with branched-chain amino acids (BCAAs) may improve recovery of patients with a posttraumatic vegetative or minimally conscious state. Design: Patients were randomly assigned to 15 days of intravenous BCAA supplementation (n=22; 19.6g/d) or an isonitrogenous placebo (n=19). Setting: Tertiary care rehabilitation setting. Participants: Patients (N=41; 29 men, 12 women; mean age, 49.5±21y) with a posttraumatic vegetative or minimally conscious state, 47±24 days after the index traumatic event. Intervention: Supplementation with BCAAs. Main Outcome Measure: Disability Rating Scale (DRS) as log10DRS. Results: Fifteen days after admission to the rehabilitation department, the log10DRS score improved significantly only in patients who had received BCAAs (log10DRS score, 1.365±0.08 to 1.294±0.05; P10DRS score in the placebo recipients remained virtually unchanged (log10DRS score, 1.373±0.03 to 1.37±0.03; P not significant). The difference in improvement of log10DRS score between the 2 groups was highly significant (P10DRS point score of .477 or higher (3 as geometric mean) that allowed them to exit the vegetative or minimally conscious state. Conclusions: Supplemented BCAAs may improve the recovery from a vegetative or minimally conscious state in patients with posttraumatic vegetative or minimally conscious state.
AB - Aquilani R, Boselli M, Boschi F, Viglio S, Iadarola P, Dossena M, Pastoris O, Verri M. Branched-chain amino acids may improve recovery from a vegetative or minimally conscious state in patients with traumatic brain injury: a pilot study. Objective: To investigate whether supplementation with branched-chain amino acids (BCAAs) may improve recovery of patients with a posttraumatic vegetative or minimally conscious state. Design: Patients were randomly assigned to 15 days of intravenous BCAA supplementation (n=22; 19.6g/d) or an isonitrogenous placebo (n=19). Setting: Tertiary care rehabilitation setting. Participants: Patients (N=41; 29 men, 12 women; mean age, 49.5±21y) with a posttraumatic vegetative or minimally conscious state, 47±24 days after the index traumatic event. Intervention: Supplementation with BCAAs. Main Outcome Measure: Disability Rating Scale (DRS) as log10DRS. Results: Fifteen days after admission to the rehabilitation department, the log10DRS score improved significantly only in patients who had received BCAAs (log10DRS score, 1.365±0.08 to 1.294±0.05; P10DRS score in the placebo recipients remained virtually unchanged (log10DRS score, 1.373±0.03 to 1.37±0.03; P not significant). The difference in improvement of log10DRS score between the 2 groups was highly significant (P10DRS point score of .477 or higher (3 as geometric mean) that allowed them to exit the vegetative or minimally conscious state. Conclusions: Supplemented BCAAs may improve the recovery from a vegetative or minimally conscious state in patients with posttraumatic vegetative or minimally conscious state.
KW - Amino acids, branched-chain
KW - Minimally conscious state
KW - Rehabilitation
UR - http://www.scopus.com/inward/record.url?scp=49949094440&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=49949094440&partnerID=8YFLogxK
U2 - 10.1016/j.apmr.2008.02.023
DO - 10.1016/j.apmr.2008.02.023
M3 - Article
C2 - 18760149
AN - SCOPUS:49949094440
VL - 89
SP - 1642
EP - 1647
JO - Archives of Physical Medicine and Rehabilitation
JF - Archives of Physical Medicine and Rehabilitation
SN - 0003-9993
IS - 9
ER -