TY - JOUR
T1 - Breakpoint distribution in constitutional chromosome rearrangements with respect to fragile sites
AU - PORFIRIO, B.
AU - DALLAPICCOLA, B.
AU - TERRENATO, L.
PY - 1987
Y1 - 1987
N2 - In an attempt to investigate possible relationships between fragile site bands and chromosome abnormalities, we have analysed the distribution of 6391 breakpoints found in constitutional rearrangements. Were relative band lengths to be ignored, a general trend for breaks to be located in fragile site bands would be confirmed. On the other hand, no difference was detected between bands with or without fragile sites if the probability of breakage for each single band is assumed to be proportional to its length. Nevertheless, a number of bands with a great excess of breakage events were identified.
AB - In an attempt to investigate possible relationships between fragile site bands and chromosome abnormalities, we have analysed the distribution of 6391 breakpoints found in constitutional rearrangements. Were relative band lengths to be ignored, a general trend for breaks to be located in fragile site bands would be confirmed. On the other hand, no difference was detected between bands with or without fragile sites if the probability of breakage for each single band is assumed to be proportional to its length. Nevertheless, a number of bands with a great excess of breakage events were identified.
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U2 - 10.1111/j.1469-1809.1987.tb01067.x
DO - 10.1111/j.1469-1809.1987.tb01067.x
M3 - Article
AN - SCOPUS:84987429634
VL - 51
SP - 329
EP - 336
JO - Annals of Human Genetics
JF - Annals of Human Genetics
SN - 0003-4800
IS - 4
ER -