Breakthrough Cancer Pain: Preliminary Data of The Italian Oncologic Pain Multisetting Multicentric Survey (IOPS-MS)

Sebastiano Mercadante, Arturo Cuomo, Augusto Caraceni, Rocco D. Mediati, Massimo Mammucari, Silvia Natoli, Marzia Lazzari, Mario Dauri, M. Airoldi, Giuseppe Azzarello, Mauro Bandera, Livio Blasi, Giacomo Cartenì, B. Chiurazzi, Benedetta Veruska Pierpaola Costanzo, D. Degiovanni, Flavio Fusco, Vittorio Guardamagna, Rosario Vincenzo Iaffaioli, S. LiguoriVito Lorusso, Sergio Mameli, Rodolfo Mattioli, Teresita Mazzei, Rita M. Melotti, Valentino Menardo, Danilo Miotti, Stefano Moroso, Stefano de Santis, R. Orsetti, Alfonso Papa, Sergio Ricci, Alessandro F. Sabato, E. Scelzi, Michele Sofia, Giuseppe Tonini, Federica Aielli, Alessandro Valle, Silvia Angelini, Daniela Iacono, Federica Mazzuca, Alessia Carnevale, Paolo Bonome, Luca Nicosia, Claudia Scaringi, Adelaide Montalto, G. Russo, Cira Antonietta Forte, Gennaro Esposito, Paola Bracchi, Ernesto Zecca, Tiziana Campa, Silvia Grecchi, Alessandra Pigni, Annunziata Sammaro, Lucia Dodaro, Giovanna Ballerini, Renato Vellucci, Clarissa Caldarulo, E. Palombo, Marco Diviza, Valentina Gianfelice, Claudia Silvestri, Simona Finocchi, Viviana Contu, Gianluca Fora, Fulvia Pedani, Massimiliano Icardi, Elisa Bellini, Alfredo Celano, Roberto Berardo, Oliviero Ostellino, Kayta Sartori, Paola Demartini, Raffaella Scroccaro, Giorgia Boscolo, Donata Sartori, Francesco Rosetti, G. Artioli, L. Borgato, Giovanni Bertoldero, Barbara Veronese, Ilaria Vallini, Alessandro Tuzi, Elena Bolzacchini, G. Pinotti, Massimiliano Alù, A. Usset, Carmela Arcuri, Agata Laudani, Alessio Pepe, Sarah Scagliarini, Massimiliano Savio Maria Sgarlata, Massimo Raimondi, Salvatore Maria Giovanni Valenti, Alberto Bucceri, Alma Kasa, Paola Budel, Anna Caramellino, Paola Ballarino, E. Donelli, Stefania Silvestro, Rossella Tonetti, S. Bozzoni, Angela Cocquio, Carmela Romano, Anna Nappi, Chiara De Divitiis, Silvia Ghidoni, Rosalba Cortinovis, Roberta Marchesi, Michele Fortis, Loredana Palermo, Giovanni Maria Pisanu, Maura Carboni, Francesca Meloni, Daniele Barillari, Luca Imperatori, Gianni Grilli, G. Laici, Sara Diacciati, P. Petreni, Boaz Samolsky Dekel, Federica Marsigli, Miriam Manfreda, Silvia Ghedini, Emanuela Bruno, Emanuele Salvini, Davide Gerboni, Serena Saulle, Roberta Carella, Gaetano Pascoletti, Silvia Bolzonello, Marta Bonotto, Silvia Ellero, Gianpiero Fasola, Elena Ongaro, Cristina Borghesi, Lucia Germani, Edoardo de Ruvo, Federica Marchetti, Milena Pasquale, Lucia Masu, Dario Tammaro, Elisabetta Saracco, Maria Teresa Di Dato, Maurizio Ferrara, Andrea Pironti, Pietro Buonavolontà, Laura Ginocchi, Gianna Musettini, Andrea Antonuzzo, C. Caparello, Maurizio Lucchesi, Azzurra Farnesi, Mari Zampieri, Manuela Pisciotta, Iacopo Fioroni, Raffaele Ratta, Maria Concetta Cursano, Daniele Santini, Cinzia Potestà, Gloria Gallo, Benhaz Saber

Research output: Contribution to journalArticle

Abstract

Introduction: An ongoing national multicenter survey [Italian Oncologic Pain multiSetting Multicentric Survey (IOPS-MS)] is evaluating the characteristics of breakthrough cancer pain (BTP) in different clinical settings. Preliminary data from the first 1500 cancer patients with BTP enrolled in this study are presented here. Methods: Thirty-two clinical centers are involved in the survey. A diagnosis of BTP was performed by a standard algorithm. Epidemiological data, Karnofsky index, stage of disease, presence and sites of metastases, ongoing oncologic treatment, and characteristics of background pain and BTP and their treatments were recorded. Background pain and BTP intensity were measured. Patients were also questioned about BTP predictability, BTP onset (≤10 or >10 min), BTP duration, background and BTP medications and their doses, time to meaningful pain relief after BTP medication, and satisfaction with BTP medication. The occurrence of adverse reactions was also assessed, as well as mucosal toxicity. Results: Background pain was well controlled with opioid treatment (numerical rating scale 3.0 ± 1.1). Patients reported 2.5 ± 1.6 BTP episodes/day with a mean intensity of 7.5 ± 1.4 and duration of 43 ± 40 min; 977 patients (65.1%) reported non-predictable BTP, and 1076 patients (71.7%) reported a rapid onset of BTP (≤10 min). Higher patient satisfaction was reported by patients treated with fast onset opioids. Conclusions: These preliminary data underline that the standard algorithm used is a valid tool for a proper diagnosis of BTP in cancer patients. Moreover, rapid relief of pain is crucial for patients’ satisfaction. The final IOPS-MS data are necessary to understand relationships between BTP characteristics and other clinical variables in oncologic patients. Funding: Molteni Farmaceutici, Italy.

Original languageEnglish
Pages (from-to)1-16
Number of pages16
JournalAdvances in Therapy
DOIs
Publication statusPublished - 2017

Keywords

  • Breakthrough pain
  • Cancer pain
  • Pain assessment
  • Rapid-onset opioid

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology (medical)

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    Mercadante, S., Cuomo, A., Caraceni, A., Mediati, R. D., Mammucari, M., Natoli, S., Lazzari, M., Dauri, M., Airoldi, M., Azzarello, G., Bandera, M., Blasi, L., Cartenì, G., Chiurazzi, B., Costanzo, B. V. P., Degiovanni, D., Fusco, F., Guardamagna, V., Iaffaioli, R. V., ... Saber, B. (2017). Breakthrough Cancer Pain: Preliminary Data of The Italian Oncologic Pain Multisetting Multicentric Survey (IOPS-MS). Advances in Therapy, 1-16. https://doi.org/10.1007/s12325-016-0440-4