TY - JOUR
T1 - Breakthroughs in the Use of Inositols for Assisted Reproductive Treatment (ART)
AU - for the Expert Group on Inositols in Preclinical and Clinical Research
AU - Facchinetti, Fabio
AU - Espinola, Maria Salome Bezerra
AU - Dewailly, Didier
AU - Ozay, Ali Cenk
AU - Prapas, Nikos
AU - Vazquez-Levin, Mónica
AU - Wdowiak, Artur
AU - Unfer, Vittorio
AU - Appetecchia, Marialuisa
AU - Aragona, Cesare
AU - Bertelli, Matteo
AU - Bevilacqua, Arturo
AU - Bizzarri, Mariano
AU - Cavalli, Pietro
AU - Copp, Andrew
AU - D'Anna, Rosario
AU - Greene, Nicholas
AU - Marín, Imelda Hernández
AU - Kamenov, Zdravko A.
AU - Kandaraki, Eleni
AU - Diamanti-Kandarakis, Evanthia
AU - Laganà, Antonio Simone
AU - Monastra, Giovanni
AU - Oliva, Mario Montanino
AU - Nestler, John E.
AU - Papalou, Olga
AU - Pkhaladze, Lali
AU - Porcaro, Giusy
AU - Soulage, Christophe O.
AU - Stringaro, Annarita
N1 - Funding Information:
V.U. and F.F. thank Dr Giovanni Monastra (Expert Group on Inositols in Preclinical and Clinical Research) for his collaboration in all phases of the realization of this review. V.U. is an employee of Lo.Li. Pharma Srl, Rome, Italy; F.F. has acted as a consultant for the same company.
Publisher Copyright:
© 2020
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/8
Y1 - 2020/8
N2 - It is well known that myo-inositol (MI) and D-chiro-inositol (DCI) are insulin-sensitizing agents, and MI is of proven utility in polycystic ovary syndrome (PCOS). In addition, MI plays a pivotal role in the physiology of reproduction, and has beneficial effects on the development of oocytes, spermatozoa, and embryos. By contrast, DCI has little effect on spermatozoa, but high concentrations in the ovary can negatively affect the quality of oocytes and the blastocyst. Overall, the evidence in the literature supports the beneficial effects of MI in both female and male reproduction, warranting clinical use of MI in assisted reproductive treatment (ART).
AB - It is well known that myo-inositol (MI) and D-chiro-inositol (DCI) are insulin-sensitizing agents, and MI is of proven utility in polycystic ovary syndrome (PCOS). In addition, MI plays a pivotal role in the physiology of reproduction, and has beneficial effects on the development of oocytes, spermatozoa, and embryos. By contrast, DCI has little effect on spermatozoa, but high concentrations in the ovary can negatively affect the quality of oocytes and the blastocyst. Overall, the evidence in the literature supports the beneficial effects of MI in both female and male reproduction, warranting clinical use of MI in assisted reproductive treatment (ART).
KW - assisted reproductive treatment
KW - D-chiro-inositol, polycystic ovary syndrome
KW - in vitro fertilization
KW - infertility
KW - myo-inositol
UR - http://www.scopus.com/inward/record.url?scp=85084702028&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85084702028&partnerID=8YFLogxK
U2 - 10.1016/j.tem.2020.04.003
DO - 10.1016/j.tem.2020.04.003
M3 - Review article
C2 - 32418772
AN - SCOPUS:85084702028
VL - 31
SP - 570
EP - 579
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
SN - 1043-2760
IS - 8
ER -