Breakthroughs in the Use of Inositols for Assisted Reproductive Treatment (ART)

for the Expert Group on Inositols in Preclinical and Clinical Research

doi:10.1016/j.tem.2020.04.003

Breakthroughs in the Use of Inositols for Assisted Reproductive Treatment (ART)

for the Expert Group on Inositols in Preclinical and Clinical Research

Istituto Regina Elena

Research output: Contribution to journal › Review article › peer-review

Abstract

It is well known that myo-inositol (MI) and D-chiro-inositol (DCI) are insulin-sensitizing agents, and MI is of proven utility in polycystic ovary syndrome (PCOS). In addition, MI plays a pivotal role in the physiology of reproduction, and has beneficial effects on the development of oocytes, spermatozoa, and embryos. By contrast, DCI has little effect on spermatozoa, but high concentrations in the ovary can negatively affect the quality of oocytes and the blastocyst. Overall, the evidence in the literature supports the beneficial effects of MI in both female and male reproduction, warranting clinical use of MI in assisted reproductive treatment (ART).

Original language	English
Pages (from-to)	570-579
Number of pages	10
Journal	Trends in Endocrinology and Metabolism
Volume	31
Issue number	8
DOIs	https://doi.org/10.1016/j.tem.2020.04.003
Publication status	Published - Aug 2020

Keywords

assisted reproductive treatment
D-chiro-inositol, polycystic ovary syndrome
in vitro fertilization
infertility
myo-inositol

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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@article{be4c215b565c4cea810cee3265e970cf,

title = "Breakthroughs in the Use of Inositols for Assisted Reproductive Treatment (ART)",

abstract = "It is well known that myo-inositol (MI) and D-chiro-inositol (DCI) are insulin-sensitizing agents, and MI is of proven utility in polycystic ovary syndrome (PCOS). In addition, MI plays a pivotal role in the physiology of reproduction, and has beneficial effects on the development of oocytes, spermatozoa, and embryos. By contrast, DCI has little effect on spermatozoa, but high concentrations in the ovary can negatively affect the quality of oocytes and the blastocyst. Overall, the evidence in the literature supports the beneficial effects of MI in both female and male reproduction, warranting clinical use of MI in assisted reproductive treatment (ART).",

keywords = "assisted reproductive treatment, D-chiro-inositol, polycystic ovary syndrome, in vitro fertilization, infertility, myo-inositol",

author = "{for the Expert Group on Inositols in Preclinical and Clinical Research} and Fabio Facchinetti and Espinola, {Maria Salome Bezerra} and Didier Dewailly and Ozay, {Ali Cenk} and Nikos Prapas and M{\'o}nica Vazquez-Levin and Artur Wdowiak and Vittorio Unfer and Marialuisa Appetecchia and Cesare Aragona and Matteo Bertelli and Arturo Bevilacqua and Mariano Bizzarri and Pietro Cavalli and Andrew Copp and Rosario D'Anna and Nicholas Greene and Mar{\'i}n, {Imelda Hern{\'a}ndez} and Kamenov, {Zdravko A.} and Eleni Kandaraki and Evanthia Diamanti-Kandarakis and Lagan{\`a}, {Antonio Simone} and Giovanni Monastra and Oliva, {Mario Montanino} and Nestler, {John E.} and Olga Papalou and Lali Pkhaladze and Giusy Porcaro and Soulage, {Christophe O.} and Annarita Stringaro",

note = "Funding Information: V.U. and F.F. thank Dr Giovanni Monastra (Expert Group on Inositols in Preclinical and Clinical Research) for his collaboration in all phases of the realization of this review. V.U. is an employee of Lo.Li. Pharma Srl, Rome, Italy; F.F. has acted as a consultant for the same company. Publisher Copyright: {\textcopyright} 2020 Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "2020",

month = aug,

doi = "10.1016/j.tem.2020.04.003",

language = "English",

volume = "31",

pages = "570--579",

journal = "Trends in Endocrinology and Metabolism",

issn = "1043-2760",

publisher = "Elsevier Inc.",

number = "8",

}

TY - JOUR

T1 - Breakthroughs in the Use of Inositols for Assisted Reproductive Treatment (ART)

AU - for the Expert Group on Inositols in Preclinical and Clinical Research

AU - Facchinetti, Fabio

AU - Espinola, Maria Salome Bezerra

AU - Dewailly, Didier

AU - Ozay, Ali Cenk

AU - Prapas, Nikos

AU - Vazquez-Levin, Mónica

AU - Wdowiak, Artur

AU - Unfer, Vittorio

AU - Appetecchia, Marialuisa

AU - Aragona, Cesare

AU - Bertelli, Matteo

AU - Bevilacqua, Arturo

AU - Bizzarri, Mariano

AU - Cavalli, Pietro

AU - Copp, Andrew

AU - D'Anna, Rosario

AU - Greene, Nicholas

AU - Marín, Imelda Hernández

AU - Kamenov, Zdravko A.

AU - Kandaraki, Eleni

AU - Diamanti-Kandarakis, Evanthia

AU - Laganà, Antonio Simone

AU - Monastra, Giovanni

AU - Oliva, Mario Montanino

AU - Nestler, John E.

AU - Papalou, Olga

AU - Pkhaladze, Lali

AU - Porcaro, Giusy

AU - Soulage, Christophe O.

AU - Stringaro, Annarita

N1 - Funding Information: V.U. and F.F. thank Dr Giovanni Monastra (Expert Group on Inositols in Preclinical and Clinical Research) for his collaboration in all phases of the realization of this review. V.U. is an employee of Lo.Li. Pharma Srl, Rome, Italy; F.F. has acted as a consultant for the same company. Publisher Copyright: © 2020 Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020/8

Y1 - 2020/8

N2 - It is well known that myo-inositol (MI) and D-chiro-inositol (DCI) are insulin-sensitizing agents, and MI is of proven utility in polycystic ovary syndrome (PCOS). In addition, MI plays a pivotal role in the physiology of reproduction, and has beneficial effects on the development of oocytes, spermatozoa, and embryos. By contrast, DCI has little effect on spermatozoa, but high concentrations in the ovary can negatively affect the quality of oocytes and the blastocyst. Overall, the evidence in the literature supports the beneficial effects of MI in both female and male reproduction, warranting clinical use of MI in assisted reproductive treatment (ART).

AB - It is well known that myo-inositol (MI) and D-chiro-inositol (DCI) are insulin-sensitizing agents, and MI is of proven utility in polycystic ovary syndrome (PCOS). In addition, MI plays a pivotal role in the physiology of reproduction, and has beneficial effects on the development of oocytes, spermatozoa, and embryos. By contrast, DCI has little effect on spermatozoa, but high concentrations in the ovary can negatively affect the quality of oocytes and the blastocyst. Overall, the evidence in the literature supports the beneficial effects of MI in both female and male reproduction, warranting clinical use of MI in assisted reproductive treatment (ART).

KW - assisted reproductive treatment

KW - D-chiro-inositol, polycystic ovary syndrome

KW - in vitro fertilization

KW - infertility

KW - myo-inositol

UR - http://www.scopus.com/inward/record.url?scp=85084702028&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85084702028&partnerID=8YFLogxK

U2 - 10.1016/j.tem.2020.04.003

DO - 10.1016/j.tem.2020.04.003

M3 - Review article

C2 - 32418772

AN - SCOPUS:85084702028

VL - 31

SP - 570

EP - 579

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

SN - 1043-2760

IS - 8

ER -