Breast adenomyoepithelioma: A case report with malignant proliferation of epithelial and myoepithelial elements

Vincenzo Petrozza, Giulia Pasciuti, Alberto Pacchiarotti, Federica Tomao, Federica Zoratto, Luigi Rossi, Antonella Fontana, Fabiana Censi, Barbara Sardella, Claudio Di Cristofano, Natale Porta, Carlo Della Rocca

Research output: Contribution to journalArticle

Abstract

Background: Breast adenomyoepithelioma is an unusual tumor characterized by a biphasic proliferation of epithelial and myoepithelial cells. Most breast adenomyoepitheliomas are considered to be benign or to have a low-grade malignant potential, characterized by propensity for local recurrence. Malignant changes arising in this lesion are extremely rare and may involve one or both cellular components.Case report: We discuss a case of a 60 year-old woman who began to experience pain in her right breast in January 2009. Breast ultrasound and mammography were performed showing a rounded, hypoechoic solid lesion with ill-defined margins in the right inner-inferior quadrant, suspicious of malignancy. Quadrantectomy of the inner-inferior quadrant of the right breast with sampling of ipsilateral axillary lymph nodes was performed. The histological analysis confirmed the diagnosis of adenomyoepithelioma with focal malignant change of the epithelial component, associated with high-grade malignant myoepithelial change. The patient was treated with adjuvant radiotherapy and her right breast received a dose of Gy 50 with a boost of Gy 10 to the tumor bed. At present, the patient shows no sign of tumor recurrence.Conclusion: Breast malignant adenomyoepithelioma is a rare tumor which should be considered in the differential diagnosis of other solid breast lesions. Only few cases have been reported in the literature. Diagnosis, optimal therapy and predicting the outcome are problematic issues due to the rarity of this disease which appears to have hematogenous rather than lymphatic spread and usually occurs in primary tumors ≥ 1.6 cm in size.

Original languageEnglish
Article number285
JournalWorld Journal of Surgical Oncology
Volume11
DOIs
Publication statusPublished - Oct 30 2013

Fingerprint

Adenomyoepithelioma
Breast
Neoplasms
Mammary Ultrasonography
Recurrence
Adjuvant Radiotherapy
Differential Diagnosis
Lymph Nodes
Epithelial Cells

Keywords

  • Breast cancer
  • Immunohistochemical
  • Malignant adenomyoepithelioma

ASJC Scopus subject areas

  • Oncology
  • Surgery

Cite this

Petrozza, V., Pasciuti, G., Pacchiarotti, A., Tomao, F., Zoratto, F., Rossi, L., ... Della Rocca, C. (2013). Breast adenomyoepithelioma: A case report with malignant proliferation of epithelial and myoepithelial elements. World Journal of Surgical Oncology, 11, [285]. https://doi.org/10.1186/1477-7819-11-285

Breast adenomyoepithelioma : A case report with malignant proliferation of epithelial and myoepithelial elements. / Petrozza, Vincenzo; Pasciuti, Giulia; Pacchiarotti, Alberto; Tomao, Federica; Zoratto, Federica; Rossi, Luigi; Fontana, Antonella; Censi, Fabiana; Sardella, Barbara; Di Cristofano, Claudio; Porta, Natale; Della Rocca, Carlo.

In: World Journal of Surgical Oncology, Vol. 11, 285, 30.10.2013.

Research output: Contribution to journalArticle

Petrozza, V, Pasciuti, G, Pacchiarotti, A, Tomao, F, Zoratto, F, Rossi, L, Fontana, A, Censi, F, Sardella, B, Di Cristofano, C, Porta, N & Della Rocca, C 2013, 'Breast adenomyoepithelioma: A case report with malignant proliferation of epithelial and myoepithelial elements', World Journal of Surgical Oncology, vol. 11, 285. https://doi.org/10.1186/1477-7819-11-285
Petrozza, Vincenzo ; Pasciuti, Giulia ; Pacchiarotti, Alberto ; Tomao, Federica ; Zoratto, Federica ; Rossi, Luigi ; Fontana, Antonella ; Censi, Fabiana ; Sardella, Barbara ; Di Cristofano, Claudio ; Porta, Natale ; Della Rocca, Carlo. / Breast adenomyoepithelioma : A case report with malignant proliferation of epithelial and myoepithelial elements. In: World Journal of Surgical Oncology. 2013 ; Vol. 11.
@article{02c56917fe8b4ce4a4a7a2fea11e8d6d,
title = "Breast adenomyoepithelioma: A case report with malignant proliferation of epithelial and myoepithelial elements",
abstract = "Background: Breast adenomyoepithelioma is an unusual tumor characterized by a biphasic proliferation of epithelial and myoepithelial cells. Most breast adenomyoepitheliomas are considered to be benign or to have a low-grade malignant potential, characterized by propensity for local recurrence. Malignant changes arising in this lesion are extremely rare and may involve one or both cellular components.Case report: We discuss a case of a 60 year-old woman who began to experience pain in her right breast in January 2009. Breast ultrasound and mammography were performed showing a rounded, hypoechoic solid lesion with ill-defined margins in the right inner-inferior quadrant, suspicious of malignancy. Quadrantectomy of the inner-inferior quadrant of the right breast with sampling of ipsilateral axillary lymph nodes was performed. The histological analysis confirmed the diagnosis of adenomyoepithelioma with focal malignant change of the epithelial component, associated with high-grade malignant myoepithelial change. The patient was treated with adjuvant radiotherapy and her right breast received a dose of Gy 50 with a boost of Gy 10 to the tumor bed. At present, the patient shows no sign of tumor recurrence.Conclusion: Breast malignant adenomyoepithelioma is a rare tumor which should be considered in the differential diagnosis of other solid breast lesions. Only few cases have been reported in the literature. Diagnosis, optimal therapy and predicting the outcome are problematic issues due to the rarity of this disease which appears to have hematogenous rather than lymphatic spread and usually occurs in primary tumors ≥ 1.6 cm in size.",
keywords = "Breast cancer, Immunohistochemical, Malignant adenomyoepithelioma",
author = "Vincenzo Petrozza and Giulia Pasciuti and Alberto Pacchiarotti and Federica Tomao and Federica Zoratto and Luigi Rossi and Antonella Fontana and Fabiana Censi and Barbara Sardella and {Di Cristofano}, Claudio and Natale Porta and {Della Rocca}, Carlo",
year = "2013",
month = "10",
day = "30",
doi = "10.1186/1477-7819-11-285",
language = "English",
volume = "11",
journal = "World Journal of Surgical Oncology",
issn = "1477-7819",
publisher = "BioMed Central",

}

TY - JOUR

T1 - Breast adenomyoepithelioma

T2 - A case report with malignant proliferation of epithelial and myoepithelial elements

AU - Petrozza, Vincenzo

AU - Pasciuti, Giulia

AU - Pacchiarotti, Alberto

AU - Tomao, Federica

AU - Zoratto, Federica

AU - Rossi, Luigi

AU - Fontana, Antonella

AU - Censi, Fabiana

AU - Sardella, Barbara

AU - Di Cristofano, Claudio

AU - Porta, Natale

AU - Della Rocca, Carlo

PY - 2013/10/30

Y1 - 2013/10/30

N2 - Background: Breast adenomyoepithelioma is an unusual tumor characterized by a biphasic proliferation of epithelial and myoepithelial cells. Most breast adenomyoepitheliomas are considered to be benign or to have a low-grade malignant potential, characterized by propensity for local recurrence. Malignant changes arising in this lesion are extremely rare and may involve one or both cellular components.Case report: We discuss a case of a 60 year-old woman who began to experience pain in her right breast in January 2009. Breast ultrasound and mammography were performed showing a rounded, hypoechoic solid lesion with ill-defined margins in the right inner-inferior quadrant, suspicious of malignancy. Quadrantectomy of the inner-inferior quadrant of the right breast with sampling of ipsilateral axillary lymph nodes was performed. The histological analysis confirmed the diagnosis of adenomyoepithelioma with focal malignant change of the epithelial component, associated with high-grade malignant myoepithelial change. The patient was treated with adjuvant radiotherapy and her right breast received a dose of Gy 50 with a boost of Gy 10 to the tumor bed. At present, the patient shows no sign of tumor recurrence.Conclusion: Breast malignant adenomyoepithelioma is a rare tumor which should be considered in the differential diagnosis of other solid breast lesions. Only few cases have been reported in the literature. Diagnosis, optimal therapy and predicting the outcome are problematic issues due to the rarity of this disease which appears to have hematogenous rather than lymphatic spread and usually occurs in primary tumors ≥ 1.6 cm in size.

AB - Background: Breast adenomyoepithelioma is an unusual tumor characterized by a biphasic proliferation of epithelial and myoepithelial cells. Most breast adenomyoepitheliomas are considered to be benign or to have a low-grade malignant potential, characterized by propensity for local recurrence. Malignant changes arising in this lesion are extremely rare and may involve one or both cellular components.Case report: We discuss a case of a 60 year-old woman who began to experience pain in her right breast in January 2009. Breast ultrasound and mammography were performed showing a rounded, hypoechoic solid lesion with ill-defined margins in the right inner-inferior quadrant, suspicious of malignancy. Quadrantectomy of the inner-inferior quadrant of the right breast with sampling of ipsilateral axillary lymph nodes was performed. The histological analysis confirmed the diagnosis of adenomyoepithelioma with focal malignant change of the epithelial component, associated with high-grade malignant myoepithelial change. The patient was treated with adjuvant radiotherapy and her right breast received a dose of Gy 50 with a boost of Gy 10 to the tumor bed. At present, the patient shows no sign of tumor recurrence.Conclusion: Breast malignant adenomyoepithelioma is a rare tumor which should be considered in the differential diagnosis of other solid breast lesions. Only few cases have been reported in the literature. Diagnosis, optimal therapy and predicting the outcome are problematic issues due to the rarity of this disease which appears to have hematogenous rather than lymphatic spread and usually occurs in primary tumors ≥ 1.6 cm in size.

KW - Breast cancer

KW - Immunohistochemical

KW - Malignant adenomyoepithelioma

UR - http://www.scopus.com/inward/record.url?scp=84887194220&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84887194220&partnerID=8YFLogxK

U2 - 10.1186/1477-7819-11-285

DO - 10.1186/1477-7819-11-285

M3 - Article

C2 - 24171817

AN - SCOPUS:84887194220

VL - 11

JO - World Journal of Surgical Oncology

JF - World Journal of Surgical Oncology

SN - 1477-7819

M1 - 285

ER -