Breast cancer and pregnancy: How safe is trastuzumab?

Research output: Contribution to journalArticle


Background. A 29-year-old woman was diagnosed with lymph-node-positive, steroid-hormone-receptor-negative and HER2/neu-positive breast cancer. She underwent surgery followed by cyclophosphamide, epirubicin, and 5-fluorouracil chemotherapy, and received radiotherapy followed by trastuzumab therapy for 1 year. During the tenth month of trastuzumab therapy, the patient reported a missed period and had a positive pregnancy test. Investigations. Physical examination, pregnancy test, echocardiography. Diagnosis. Unintended pregnancy during adjuvant trastuzumab therapy. Management. Cessation of trastuzumab and close monitoring of mother and fetus during pregnancy.

Original languageEnglish
Pages (from-to)367-370
Number of pages4
JournalNature Reviews Clinical Oncology
Issue number6
Publication statusPublished - 2009

ASJC Scopus subject areas

  • Oncology
  • Medicine(all)

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