Background. A 29-year-old woman was diagnosed with lymph-node-positive, steroid-hormone-receptor-negative and HER2/neu-positive breast cancer. She underwent surgery followed by cyclophosphamide, epirubicin, and 5-fluorouracil chemotherapy, and received radiotherapy followed by trastuzumab therapy for 1 year. During the tenth month of trastuzumab therapy, the patient reported a missed period and had a positive pregnancy test. Investigations. Physical examination, pregnancy test, echocardiography. Diagnosis. Unintended pregnancy during adjuvant trastuzumab therapy. Management. Cessation of trastuzumab and close monitoring of mother and fetus during pregnancy.
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