Breast cancer and timing of surgery during menstrual cycle: A 5-year analysis of 248 premenopausal women

Michelc Milella, Cecilia Nisticò, Virginia Ferraresi, Angela Vaccaro, Alessandra Fabi, Anna Maria D'Ottavio, Claudio Botti, Diana Giannarelli, Massimo Lopez, Enrico Cortesi, Carlo Maria Foggi, Mauro Antimi, Edmondo Terzoli, Francesco Cognetti, Paola Papaldo

Research output: Contribution to journalArticlepeer-review

Abstract

In the present report, we retrospectively analyzed the impact of the timing of surgery during menstrual cycle on disease-free and overall survival of 248 premenopausal patients with stage I/II breast cancer who underwent surgery followed by anthracycline-containing adjuvant chemotherapy. With a median follow-up of 5 years, no statistically significant differences were observed in disease-free or overall survival between women operated upon during the follicular (days 0-14) and the luteal (days 15-32) phase of the menstrual cycle. The impact on disease-free and overall survival of lymph-node status, tumor size and hormone receptor expression, but not of the phase of the menstrual cycle at the time of surgery, was confirmed by univariate and multivariate analysis. However, when combined with hormone receptor status, the phase of the menstrual cycle at the time of surgery proved useful to better define the prognosis of primary breast cancer patients, with significantly longer disease-free and overall survival for patients operated upon during the follicular phase and with positive hormone receptors.

Original languageEnglish
Pages (from-to)259-266
Number of pages8
JournalBreast Cancer Research and Treatment
Volume55
Issue number3
DOIs
Publication statusPublished - 1999

Keywords

  • Breast cancer
  • Menstrual cycle phase
  • Premenopausal
  • Prognosis
  • Surgery

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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