Abstract
Metabolic reprogramming refers to the ability of cancer cells to alter their metabolism in order to support the increased energy request due to continuous growth, rapid proliferation, and other characteristics typical of neoplastic cells. It has long been believed that the increase of metabolic request was independent of the mitochondrial action but recently we know that mitochondrial activity together with metabolism plays a pivotal role in the regulation of the energy needed for tumor cell growth and proliferation. For these reasons the mitochondria pathways could be a new target for therapeutic and chemopreventive intervention. Metformin in particular is actually considered a promising agent against mitochondrial activity thanks to its ability to inhibit the mitochondrial complex I.
| Original language | English |
|---|---|
| Article number | 972193 |
| Journal | BioMed Research International |
| Volume | 2015 |
| DOIs | |
| Publication status | Published - 2015 |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Immunology and Microbiology(all)
Cite this
Breast Cancer Metabolism and Mitochondrial Activity : The Possibility of Chemoprevention with Metformin. / Cazzaniga, Massimiliano; Bonanni, Bernardo.
In: BioMed Research International, Vol. 2015, 972193, 2015.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Breast Cancer Metabolism and Mitochondrial Activity
T2 - The Possibility of Chemoprevention with Metformin
AU - Cazzaniga, Massimiliano
AU - Bonanni, Bernardo
PY - 2015
Y1 - 2015
N2 - Metabolic reprogramming refers to the ability of cancer cells to alter their metabolism in order to support the increased energy request due to continuous growth, rapid proliferation, and other characteristics typical of neoplastic cells. It has long been believed that the increase of metabolic request was independent of the mitochondrial action but recently we know that mitochondrial activity together with metabolism plays a pivotal role in the regulation of the energy needed for tumor cell growth and proliferation. For these reasons the mitochondria pathways could be a new target for therapeutic and chemopreventive intervention. Metformin in particular is actually considered a promising agent against mitochondrial activity thanks to its ability to inhibit the mitochondrial complex I.
AB - Metabolic reprogramming refers to the ability of cancer cells to alter their metabolism in order to support the increased energy request due to continuous growth, rapid proliferation, and other characteristics typical of neoplastic cells. It has long been believed that the increase of metabolic request was independent of the mitochondrial action but recently we know that mitochondrial activity together with metabolism plays a pivotal role in the regulation of the energy needed for tumor cell growth and proliferation. For these reasons the mitochondria pathways could be a new target for therapeutic and chemopreventive intervention. Metformin in particular is actually considered a promising agent against mitochondrial activity thanks to its ability to inhibit the mitochondrial complex I.
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UR - http://www.scopus.com/inward/citedby.url?scp=84947461275&partnerID=8YFLogxK
U2 - 10.1155/2015/972193
DO - 10.1155/2015/972193
M3 - Article
VL - 2015
JO - BioMed Research International
JF - BioMed Research International
SN - 2314-6133
M1 - 972193
ER -